Evidence map›Paper›PMID 27780725›Full record

ArticleEuropean journal of pharmacology2016

In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations.

Federica Ferrari, Maria Camilla Cerlesi, Davide Malfacini, Laila Asth, Elaine C Gavioli, Blair V Journigan, Uma Gayathri Kamakolanu, Michael E Meyer, Dennis Yasuda, Willma E Polgar and 5 more

Abstract read
In one paragraph

Article in European journal of pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Federica FerrariSection of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy.
Maria Camilla CerlesiSection of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy.
Davide MalfaciniSection of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy.
Laila AsthBehavioral Pharmacology Laboratory, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Elaine C GavioliBehavioral Pharmacology Laboratory, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Blair V JourniganAstraea Therapeutics, LLC. 320 Logue Avenue, Mountain View, CA, USA.
Uma Gayathri KamakolanuAstraea Therapeutics, LLC. 320 Logue Avenue, Mountain View, CA, USA.
Michael E MeyerAstraea Therapeutics, LLC. 320 Logue Avenue, Mountain View, CA, USA.
Dennis YasudaAstraea Therapeutics, LLC. 320 Logue Avenue, Mountain View, CA, USA.
Willma E PolgarSRI International, Biosciences Division, 333 Ravenswood Avenue, Menlo Park, CA, USA.
Anna RizziSection of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy.
Remo GuerriniDepartment of Chemical and Pharmaceutical Sciences and LTTA, University of Ferrara, Italy.
Chiara RuzzaSection of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy.
Nurulain T ZaveriAstraea Therapeutics, LLC. 320 Logue Avenue, Mountain View, CA, USA.
Girolamo CaloSection of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy. Electronic address: g.calo@unife.it.

Funding

DISCOVERY OF SMALL-MOLECULE ORPHANIN FQ RECEPTOR LIGANDSR01DA014026 · NIDA · SRI INTERNATIONAL · PI ZAVERI, NURULAIN T · 2001 to 2011
$3.4M
Discovery of Bifunctional NOP/Opioid Receptor Ligands for Drug Abuse TherapyR01DA027811 · NIDA · ASTRAEA THERAPEUTICS, LLC · PI ZAVERI, NURULAIN T · 2009 to 2014
$3.4M
A NOVEL APPROACH FOR PAIN TREATMENT WITHOUT OPIOID LIABILITIESR44DA042465 · NIDA · ASTRAEA THERAPEUTICS, LLC · PI ZAVERI, NURULAIN T · 2016 to 2017
$1.5M
Development of Novel Therapies for Levodopa-induced Dyskinesia in Parkinson's DisR43NS070664 · NINDS · ASTRAEA THERAPEUTICS, LLC · PI ZAVERI, NURULAIN T · 2010 to 2010
$241k
NIDA NIH HHS R01 DA014026NIDA NIH HHS R01 DA027811NIDA NIH HHS R44 DA042465NINDS NIH HHS R43 NS070664
6 · The paper itself

Abstract

Nociceptin/Orphanin FQ (N/OFQ) regulates several biological functions via selective activation of the N/OFQ receptor (NOP). In this study novel nonpeptide NOP ligands were characterized in vitro in receptor binding and [

Indexed as

AnimalsCHO CellsColonCricetinaeCricetulusCycloheptanesHEK293 CellsHumansLigandsMaleMiceNociceptin ReceptorPiperidinesReceptors, OpioidRecombinant ProteinsVas Deferenscis-1-methyl-7-((4-(2,6-dichlorophenyl)piperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-olCycloheptanesLigandsNociceptin ReceptorPiperidinesReceptors, OpioidRecombinant ProteinsBioluminescence resonance energy transferCalcium mobilization and mouse colon vas deferens and assaysNOP and classical opioid receptorsReceptor and [(35)S]GTPγS binding

Identifiers

PMID27780725
PMCPMC5555400

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.