Evidence map›Paper›PMID 27780701›Full record

ArticleAmerican journal of obstetrics and gynecology2017

Threatened preterm labor is a risk factor for impaired cognitive development in early childhood.

Cristina Paules, Victoria Pueyo, Elena Martí, Susana de Vilchez, Irina Burd, Pilar Calvo, Daniel Oros

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In one paragraph

Article in American journal of obstetrics and gynecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  20. The frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Cristina PaulesISS Aragón, Obstetrics Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, University of Zaragoza, Zaragoza, Spain.
Victoria PueyoISS Aragón, Ophthalmology Department, Hospital Universitario Miguel Servet Zaragoza, University of Zaragoza, Zaragoza, Spain. Electronic address: vpueyo@unizar.es.
Elena MartíISS Aragón, Psychology Department, University of Zaragoza, Zaragoza, Spain.
Susana de VilchezISS Aragón, Psychology Department, University of Zaragoza, Zaragoza, Spain.
Irina BurdIntegrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD.
Pilar CalvoISS Aragón, Obstetrics Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, University of Zaragoza, Zaragoza, Spain.
Daniel OrosISS Aragón, Obstetrics Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, University of Zaragoza, Zaragoza, Spain.
Universidad de Zaragoza · ESJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThreatened preterm labor is a leading cause of hospital admission during pregnancy. Patients with an episode of threatened preterm labor who deliver at term are considered to have false preterm labor. However, threatened preterm labor has been proposed as a pathologic insult that is not always sufficient to induce irreversible spontaneous preterm birth but that could alter the normal course of pregnancy.

objectiveThe aim of this study was to evaluate threatened preterm labor during pregnancy as a risk factor of neurodevelopmental deficits of children at 2 years of age. STUDY

designTwo-year-old children who were born late preterm (n=22) or at term after threatened preterm labor (n=23) were compared with at-term control children (n=42). Neurodevelopment was evaluated at a corrected age of 24-29 months with the use of the Merrill-Palmer-Revised Scales of Development.

resultsChildren who were born at term after threatened preterm labor had lower scores than control children on global cognitive index (95.4 vs 104.2; P=.011), cognition (95.1 vs 103.1; P=.021), fine motor (95.2 vs 103.4; P=.003), gross motor (84.7 vs 99.8; P=.001), memory (92.9 vs 100.4; P=.015), receptive language (93.9 vs 102.9; P=.03), speed of processing (105.7 vs 113.3; P=.011), and visual motor coordination (98.8 vs 106.7; P=.003) subtests. Children born at term after threatened preterm labor had an increased risk of mild neurodevelopmental delay compared with control children (odds ratio for global cognitive index, 2.06; 95% confidence interval, 1.09-3.88; P=.033). There were no significant differences in any cognitive domain between children who were born late preterm and children who were born at term after threatened preterm labor.

conclusionsThreatened preterm labor is a risk factor for impaired cognitive development at 2 years of age, even if birth occurred at term.

Indexed as

Child DevelopmentCognitionTerm BirthAdultChild, PreschoolCohort StudiesFemaleHumansMaleNeurodevelopmental DisordersObstetric Labor, PrematurePregnancyPrenatal Exposure Delayed EffectsProspective Studiesneurodevelopmentpreterm birththreatened preterm labor

Identifiers

PMID27780701
OpenAlexW2533331525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.