Evidence map›Paper›PMID 27780064›Full record

ArticleCurrent biology : CB2016

Axonal Degeneration: RIPK1 Multitasking in ALS.

Kristin Politi, Serge Przedborski

Abstract readComment
PubMed Publisher
In one paragraph

Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Kristin PolitiDepartments of Pathology & Cell Biology, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA; The Center for Motor Neuron Biology and Disease, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA.
Serge PrzedborskiDepartments of Pathology & Cell Biology, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA; The Center for Motor Neuron Biology and Disease, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA; Department of Neurology, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA. Electronic address: sp30@columbia.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A recent study reports that microglia and oligodendrocytes promote motor neuron degeneration by inducing inflammation and necroptosis in a manner dependent on receptor-interacting kinase 1 (RIPK1). These findings could be significant for our understanding of the neurobiology and treatment of neurodegenerative diseases like amyotrophic lateral sclerosis.

Indexed as

Amyotrophic Lateral SclerosisNeurodegenerative DiseasesApoptosisHumansInflammationReceptor-Interacting Protein Serine-Threonine KinasesReceptor-Interacting Protein Serine-Threonine KinasesRIPK1 protein, human

Identifiers

PMID27780064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.