Evidence map›Paper›PMID 27780031›Full record

SynthesisJournal of psychiatry & neuroscience : JPN2017

Microstructural brain abnormalities in medication-free patients with major depressive disorder: a systematic review and meta-analysis of diffusion tensor imaging.

Jing Jiang, You-Jin Zhao, Xin-Yu Hu, Ming-Ying Du, Zi-Qi Chen, Min Wu, Kai-Ming Li, Hong-Yan Zhu, Poornima Kumar, Qi-Yong Gong

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 17 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 17 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Trial
  19. Trial
  20. Trial

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jing JiangFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Psychoradiology and Psychiatry, West China Hospital and Schools of Clinical Medicine, Sichuan University, Chengdu, China (Jiang, Zhao, Hu, Du, Chen, Wu, Li, Zhu, Gong); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China (Zhu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass., USA (Kumar); Department of Psychiatry, Harvard Medical School, Boston, Mass., USA (Kumar); the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA (Gong).
You-Jin ZhaoFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Psychoradiology and Psychiatry, West China Hospital and Schools of Clinical Medicine, Sichuan University, Chengdu, China (Jiang, Zhao, Hu, Du, Chen, Wu, Li, Zhu, Gong); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China (Zhu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass., USA (Kumar); Department of Psychiatry, Harvard Medical School, Boston, Mass., USA (Kumar); the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA (Gong).
Xin-Yu HuFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Psychoradiology and Psychiatry, West China Hospital and Schools of Clinical Medicine, Sichuan University, Chengdu, China (Jiang, Zhao, Hu, Du, Chen, Wu, Li, Zhu, Gong); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China (Zhu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass., USA (Kumar); Department of Psychiatry, Harvard Medical School, Boston, Mass., USA (Kumar); the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA (Gong).
Ming-Ying DuFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Psychoradiology and Psychiatry, West China Hospital and Schools of Clinical Medicine, Sichuan University, Chengdu, China (Jiang, Zhao, Hu, Du, Chen, Wu, Li, Zhu, Gong); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China (Zhu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass., USA (Kumar); Department of Psychiatry, Harvard Medical School, Boston, Mass., USA (Kumar); the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA (Gong).
Zi-Qi ChenFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Psychoradiology and Psychiatry, West China Hospital and Schools of Clinical Medicine, Sichuan University, Chengdu, China (Jiang, Zhao, Hu, Du, Chen, Wu, Li, Zhu, Gong); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China (Zhu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass., USA (Kumar); Department of Psychiatry, Harvard Medical School, Boston, Mass., USA (Kumar); the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA (Gong).
Min WuFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Psychoradiology and Psychiatry, West China Hospital and Schools of Clinical Medicine, Sichuan University, Chengdu, China (Jiang, Zhao, Hu, Du, Chen, Wu, Li, Zhu, Gong); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China (Zhu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass., USA (Kumar); Department of Psychiatry, Harvard Medical School, Boston, Mass., USA (Kumar); the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA (Gong).
Kai-Ming LiFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Psychoradiology and Psychiatry, West China Hospital and Schools of Clinical Medicine, Sichuan University, Chengdu, China (Jiang, Zhao, Hu, Du, Chen, Wu, Li, Zhu, Gong); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China (Zhu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass., USA (Kumar); Department of Psychiatry, Harvard Medical School, Boston, Mass., USA (Kumar); the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA (Gong).
Hong-Yan ZhuFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Psychoradiology and Psychiatry, West China Hospital and Schools of Clinical Medicine, Sichuan University, Chengdu, China (Jiang, Zhao, Hu, Du, Chen, Wu, Li, Zhu, Gong); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China (Zhu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass., USA (Kumar); Department of Psychiatry, Harvard Medical School, Boston, Mass., USA (Kumar); the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA (Gong).
Poornima KumarFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Psychoradiology and Psychiatry, West China Hospital and Schools of Clinical Medicine, Sichuan University, Chengdu, China (Jiang, Zhao, Hu, Du, Chen, Wu, Li, Zhu, Gong); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China (Zhu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass., USA (Kumar); Department of Psychiatry, Harvard Medical School, Boston, Mass., USA (Kumar); the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA (Gong).
Qi-Yong GongFrom the Huaxi MR Research Center (HMRRC), Department of Radiology, Psychoradiology and Psychiatry, West China Hospital and Schools of Clinical Medicine, Sichuan University, Chengdu, China (Jiang, Zhao, Hu, Du, Chen, Wu, Li, Zhu, Gong); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China (Zhu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass., USA (Kumar); Department of Psychiatry, Harvard Medical School, Boston, Mass., USA (Kumar); the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA (Gong).
Harvard University · USMcLean Hospital · USState Key Laboratory of BiotherapyYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple meta-analyses of diffusion tensor imaging (DTI) studies have reported impaired white matter integrity in patients with major depressive disorder (MDD). However, owing to inclusion of medicated patients in these studies, it is difficult to conclude whether these reported alterations are associated with MDD or confounded by medication effects. A meta-analysis of DTI studies on medication-free (medication-naive and medication washout) patients with MDD would therefore be necessary to disentangle MDD-specific effects.

methodsWe analyzed white matter alterations between medication-free patients with MDD and healthy controls using anisotropic effect size-signed differential mapping (AES-SDM). We used DTI query software for fibre tracking.

resultsBoth pooled and subgroup meta-analyses in medication washout patients showed robust fractional anisotropy (FA) reductions in white matter of the right cerebellum hemispheric lobule, body of the corpus callosum (CC) and bilateral superior longitudinal fasciculus III (SLF III), whereas FA reductions in the genu of the CC and right anterior thalamic projections were seen in only medication-naive patients. Fibre tracking showed that the main tracts with observed FA reductions included the right cerebellar tracts, body of the CC, bilateral SLF III and arcuate fascicle. LIMITATIONS: The analytic techniques, patient characteristics and clinical variables of the included studies were heterogeneous; we could not exclude the effects of nondrug therapies owing to a lack of data.

conclusionBy excluding the confounding influences of current medication status, findings from the present study may provide a better understanding of the underlying neuropathology of MDD.

Indexed as

BrainDiffusion Tensor ImagingHumansMajor Depressive DisorderWhite Matter

Identifiers

PMID27780031
PMCPMC5403660
OpenAlexW2542536236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.