Evidence map›Paper›PMID 27779916›Full record

ArticleEndocrinology2016

Developmental and Thyroid Hormone Regulation of the DNA Methyltransferase 3a Gene in Xenopus Tadpoles.

Yasuhiro Kyono, Laurent M Sachs, Patrice Bilesimo, Luan Wen, Robert J Denver

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  3. Thyroid hormone links environmental signals to DNA methylation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yasuhiro KyonoNeuroscience Graduate Program (Y.K.), The University of Michigan, Ann Arbor, Michigan 48109-1048; UMR-7221, Centre National de la Recherche Scientifique (L.M.S., P.B.), Muséum National d'Histoire Naturelle, 75005 Paris, France; and Department of Molecular, Cellular, and Developmental Biology (L.W., R.J.D.), The University of Michigan, Ann Arbor, Michigan 48109-1048.
Laurent M SachsNeuroscience Graduate Program (Y.K.), The University of Michigan, Ann Arbor, Michigan 48109-1048; UMR-7221, Centre National de la Recherche Scientifique (L.M.S., P.B.), Muséum National d'Histoire Naturelle, 75005 Paris, France; and Department of Molecular, Cellular, and Developmental Biology (L.W., R.J.D.), The University of Michigan, Ann Arbor, Michigan 48109-1048.
Patrice BilesimoNeuroscience Graduate Program (Y.K.), The University of Michigan, Ann Arbor, Michigan 48109-1048; UMR-7221, Centre National de la Recherche Scientifique (L.M.S., P.B.), Muséum National d'Histoire Naturelle, 75005 Paris, France; and Department of Molecular, Cellular, and Developmental Biology (L.W., R.J.D.), The University of Michigan, Ann Arbor, Michigan 48109-1048.
Luan WenNeuroscience Graduate Program (Y.K.), The University of Michigan, Ann Arbor, Michigan 48109-1048; UMR-7221, Centre National de la Recherche Scientifique (L.M.S., P.B.), Muséum National d'Histoire Naturelle, 75005 Paris, France; and Department of Molecular, Cellular, and Developmental Biology (L.W., R.J.D.), The University of Michigan, Ann Arbor, Michigan 48109-1048.
Robert J DenverNeuroscience Graduate Program (Y.K.), The University of Michigan, Ann Arbor, Michigan 48109-1048; UMR-7221, Centre National de la Recherche Scientifique (L.M.S., P.B.), Muséum National d'Histoire Naturelle, 75005 Paris, France; and Department of Molecular, Cellular, and Developmental Biology (L.W., R.J.D.), The University of Michigan, Ann Arbor, Michigan 48109-1048.
University of Michigan–Ann Arbor · US

Funding

PUBLIC HEALTH DEMONSTRATIONP60DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1985 to 2012
$26.5M
Early Stage Training in the NeurosciencesT32NS076401 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias, LESLIE S. SATIN · 2011 to 2026
$3.1M
Thyroid hormone regulates DNA methylation in the developing brain through direct modulation of the DNA methyltransferase 3a geneR21NS088062 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DENVER, ROBERT J · 2015 to 2016
$412k
Thyroid hormone-dependent DNA methylation in the developing brainF31NS073294 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KYONO, YASUHIRO · 2011 to 2012
$64k
NIDDK NIH HHS P60 DK020572NINDS NIH HHS F31 NS073294NINDS NIH HHS R21 NS088062NINDS NIH HHS T32 NS076401
6 · The paper itself

Abstract

Thyroid hormone is essential for normal development in vertebrates. In amphibians, T3 controls metamorphosis by inducing tissue-specific gene regulation programs. A hallmark of T3 action is the modification of chromatin structure, which underlies changes in gene transcription. We found that mRNA for the de novo DNA methyltransferase (DNMT) dnmt3a, but not dnmt1, increased in the brain of Xenopus tadpoles during metamorphosis in parallel with plasma [T3]. Addition of T

Indexed as

AnimalsBrainCell LineDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AGene Expression Regulation, DevelopmentalLarvaMetamorphosis, BiologicalTranscription, GeneticTriiodothyronineXenopus laevisDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADnmt3a protein, mouseTriiodothyronine

Identifiers

PMID27779916
PMCPMC5133355
OpenAlexW2536256680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.