Evidence map›Paper›PMID 27779859›Full record

ArticleAnalytical chemistry2016

Continuous Fluorescence Assays for Reactions Involving Adenine.

Ross S Firestone, Scott A Cameron, Peter C Tyler, Rodrigo G Ducati, Adam Z Spitz, Vern L Schramm

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Inverse heavy enzyme isotope effects in methylthioadenosine nucleosidases.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ross S FirestoneDepartment of Biochemistry, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, New York 10461, United States.
Scott A CameronDepartment of Biochemistry, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, New York 10461, United States.
Peter C TylerThe Ferrier Research Institute, Victoria University of Wellington , Lower Hutt, Wellington 6140, New Zealand.
Rodrigo G DucatiDepartment of Biochemistry, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, New York 10461, United States.
Adam Z SpitzDepartment of Biochemistry, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, New York 10461, United States.
Vern L SchrammDepartment of Biochemistry, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, New York 10461, United States.
Albert Einstein College of Medicine · USVictoria University of Wellington · NZ

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Transition State Analogues as Modulators of DNA MethylationR01CA135405 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SCHRAMM, VERN L. · 2008 to 2018
$2.8M
Designing Novel Anti-Cancer Therapeutics: Targeting Methionine MetabolismF30CA210372 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FIRESTONE, ROSS · 2017 to 2019
$132k
NCI NIH HHS F30 CA210372NCI NIH HHS R01 CA135405NIGMS NIH HHS T32 GM007288
6 · The paper itself

Abstract

5'-Methylthioadenosine phosphorylase (MTAP) and 5'-methylthioadenosine nucleosidase (MTAN) catalyze the phosphorolysis and hydrolysis of 5'-methylthioadenosine (MTA), respectively. Both enzymes have low K

Indexed as

Fluorescence2-AminopurineAdenineAdenine PhosphoribosyltransferaseEnzyme AssaysHumansKineticsSaccharomyces cerevisiaeSubstrate Specificity2,6-diaminopurine2-AminopurineAdenineAdenine Phosphoribosyltransferase

Identifiers

PMID27779859
PMCPMC5434977
OpenAlexW2532366952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.