ArticleJournal of magnetic resonance imaging : JMRI2017
Quantification of breast stiffness using MR elastography at 3 Tesla with a soft sternal driver: A reproducibility study.
Article in Journal of magnetic resonance imaging : JMRI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Tissue-stiffness-driven platelet activation emerges as a potential target for breast cancer prevention and treatment.Cell communication and signaling : CCS · 2026Article
- Correlation Between Breast Parenchymal Stiffness Measured by 3T Magnetic Resonance Elastography and CT-Derived Hounsfield Units.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Differentiating Breast Tissue Stiffness With Magnetic Resonance Elastography (MRE): A Focus on Fibroglandular and Fatty Tissues.NMR in biomedicine · 2025Article
- Review
- Association between patient position-induced breast shape changes on prone and supine MRI and mammographic breast density or thickness.Japanese journal of radiology · 2025Observational
- Magnetic Resonance Elastography of Invasive Breast Cancer: Evaluating Prognostic Factors and Treatment Response.Tomography (Ann Arbor, Mich.) · 2025Article
- Magnetic Resonance Elastography for Breast Cancer Diagnosis Through the Assessment of Tissue Biomechanical Properties.Health science reports · 2024Article
- A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis.Frontiers in bioengineering and biotechnology · 2023Review
- Association of breast cancer risk, density, and stiffness: global tissue stiffness on breast MR elastography (MRE).Breast cancer research and treatment · 2022Article
- Design, Construction, and Implementation of a Magnetic Resonance Elastography Actuator for Research Purposes.Current protocols · 2022Article
- Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer.Nature communications · 2021Article
- Novel approach in the evaluation of ultrasound BI-RADS 3 & 4 breast masses with a combination method of elastography & Doppler.The Indian journal of medical research · 2021Article
- Current State of Breast Cancer Diagnosis, Treatment, and Theranostics.Pharmaceutics · 2021Review
- MR Elastography of the Breast: Evolution of Technique, Case Examples, and Future Directions.Clinical breast cancer · 2021Review
- Poroelasticity as a Model of Soft Tissue Structure: Hydraulic Permeability Reconstruction for Magnetic Resonance Elastography in Silico.Frontiers in physics · 2021Article
- Distinct phenotypes of cancer cells on tissue matrix gel.Breast cancer research : BCR · 2020Article
- Imaging brain function with simultaneous BOLD and viscoelasticity contrast: fMRI/fMRE.NeuroImage · 2020Article
- Evaluation of breast stiffness measured by ultrasound and breast density measured by MRI using a prone-supine deformation model.Biomarker research · 2019Article
- Advances and Future Direction of Magnetic Resonance Elastography.Topics in magnetic resonance imaging : TMRI · 2018Review
- Stiffness reconstruction methods for MR elastography.NMR in biomedicine · 2018Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposePrevious studies of breast MR elastography (MRE) evaluated the technique at magnetic field strengths of 1.5 Tesla (T) with the breast in contact with the driver. The aim of this study is to evaluate breast stiffness measurements and their reproducibility using a soft sternal driver at 3T and compare the results with qualitative measures of breast density. MATERIALS AND
methodsTwenty-two healthy volunteers each underwent two separate breast MRE scans in a 3T MRI. MRE vibrations were introduced into the breasts at 60 Hz using a soft sternal driver and axial slices were collected using a gradient echo MRE sequence. Mean stiffness measurements were calculated for each volunteer as well as a measure of reproducibility using concordance correlation between scans. Mean stiffness values for each volunteer were assessed and related to amounts of fibroglandular tissue (i.e., breast lobules, ducts, and fibrous connective tissue).
resultsThe stiffness values were reproducible with a significant P-value < 0.0001 between two scans with concordance correlation of 0.87 and 0.91 for center slice and grouping all slices, respectively. Volunteers with dense breasts (i.e., higher grades of fibroglandular tissue) had mean stiffness values of 0.96 kPa (center slice) and 0.92 kPa (all slices) while those without dense breasts had mean stiffness values of 0.85 kPa (center slice) and 0.83 kPa (all slices) (P ≤ 0.05).
conclusionBreast MRE is a reproducible technique at 3T using a soft sternal driver. Dense breasts had significantly higher stiffness measurements compared with nondense breasts. LEVEL OF EVIDENCE: 2 J. MAGN. RESON. IMAGING 2017;45:1379-1384.
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