ArticleTranslational psychiatry2016
SNP-based heritability estimates of the personality dimensions and polygenic prediction of both neuroticism and major depression: findings from CONVERGE.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Genome-wide Scan of Dental Fear and Anxiety Nominates Novel Genes.Journal of dental research · 2022Pooled it
- A standardized personality lexicon for enhancing personalized human-machine interaction.Scientific data · 2026Article
- Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.Nutrients · 2025Article
- Divorce, genetic risk, and suicidal thoughts and behaviors in a sample with recurrent major depressive disorder.Journal of affective disorders · 2024Article
- Gene-environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding.Personality neuroscience · 2023Article
- Current State and Challenges of the Global Outcomes of Dental Caries Research in the Meta-Omics Era.Frontiers in cellular and infection microbiology · 2022Review
- Morphometry of the Hippocampus Across the Adult Life-Span in Patients with Depressive Disorders: Association with Neuroticism.Brain topography · 2021Article
- Maternal postnatal depression and offspring depression at age 24 years in a UK-birth cohort: the mediating role of maternal nurturing behaviours concerning feeding, crying and sleeping.Wellcome open research · 2021Article
- Cortical surface area alterations shaped by genetic load for neuroticism.Molecular psychiatry · 2020Article
- Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents.Translational psychiatry · 2020Article
- The complex genetics and biology of human temperament: a review of traditional concepts in relation to new molecular findings.Translational psychiatry · 2019Review
- Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women.Brain and behavior · 2019Article
- Consortium-based genome-wide meta-analysis for childhood dental caries traits.Human molecular genetics · 2018Article
- Polygenic prediction of the phenome, across ancestry, in emerging adulthood.Psychological medicine · 2018Article
- Opportunities for an enhanced integration of neuroscience and genomics.Brain imaging and behavior · 2018Review
- Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.Annual review of clinical psychology · 2018Review
- Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women.Psychological medicine · 2018Article
- The genetics of human personality.Genes, brain, and behavior · 2018Review
- Childhood behaviour problems show the greatest gap between DNA-based and twin heritability.Translational psychiatry · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Biometrical genetic studies suggest that the personality dimensions, including neuroticism, are moderately heritable (~0.4 to 0.6). Quantitative analyses that aggregate the effects of many common variants have recently further informed genetic research on European samples. However, there has been limited research to date on non-European populations. This study examined the personality dimensions in a large sample of Han Chinese descent (N=10 064) from the China, Oxford, and VCU Experimental Research on Genetic Epidemiology study, aimed at identifying genetic risk factors for recurrent major depression among a rigorously ascertained cohort. Heritability of neuroticism as measured by the Eysenck Personality Questionnaire (EPQ) was estimated to be low but statistically significant at 10% (s.e.=0.03, P=0.0001). In addition to EPQ, neuroticism based on a three-factor model, data for the Big Five (BF) personality dimensions (neuroticism, openness, conscientiousness, extraversion and agreeableness) measured by the Big Five Inventory were available for controls (n=5596). Heritability estimates of the BF were not statistically significant despite high power (>0.85) to detect heritabilities of 0.10. Polygenic risk scores constructed by best linear unbiased prediction weights applied to split-half samples failed to significantly predict any of the personality traits, but polygenic risk for neuroticism, calculated with LDpred and based on predictive variants previously identified from European populations (N=171 911), significantly predicted major depressive disorder case-control status (P=0.0004) after false discovery rate correction. The scores also significantly predicted EPQ neuroticism (P=6.3 × 10
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