Evidence map›Paper›PMID 27779421›Full record

ArticleAmerican journal of respiratory and critical care medicine2017

Parametric Response Mapping as an Imaging Biomarker in Lung Transplant Recipients.

Elizabeth A Belloli, Irina Degtiar, Xin Wang, Gregory A Yanik, Linda J Stuckey, Stijn E Verleden, Ella A Kazerooni, Brian D Ross, Susan Murray, Craig J Galbán and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The emerging role of quantitative imaging in asthma.The British journal of radiology · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Elizabeth A Belloli1 Division of Pulmonary and Critical Care Medicine.
Irina Degtiar2 Department of Biostatistics, and.
Xin Wang2 Department of Biostatistics, and.
Gregory A Yanik3 Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan; and.
Linda J Stuckey4 Department of Pharmacy, and.
Stijn E Verleden5 Lung Transplant Unit, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium.
Ella A Kazerooni6 Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan.
Brian D Ross6 Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan.
Susan Murray2 Department of Biostatistics, and.
Craig J Galbán6 Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan.
Vibha N Lama1 Division of Pulmonary and Critical Care Medicine.
Cancer Research And Biostatistics · USMichigan Medicine · USPulmonary and Critical Care Associates · USKU Leuven · BEUniversity of Michigan · US

Funding

QUANTITATION OF HUMAN BRAIN TUMOR THERAPY RESPONSE BY MRP01CA085878 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHENEVERT, THOMAS L · 2001 to 2017
$31.9M
Translational Dysregulation Driving Mesenchymal Cell Fibrogenic Transformation and Chronic Lung Allograft DysfunctionR01HL094622 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAMA, VIBHA N · 2009 to 2023
$5.9M
Imaging of Hematologic and Oncologic DisordersR35CA197701 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSS, BRIAN D. · 2016 to 2022
$5.9M
Parametric Response Mapping in COPDR01HL122438 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAN, MEILAN K, MARTINEZ, FERNANDO J · 2014 to 2017
$4.0M
Autotaxin Lysophophatidic acid pathway in bronchiolitis obliterans post-lung tranR01HL118017 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAMA, VIBHA N · 2014 to 2017
$2.0M
CT-based Biomarker for Diagnosis of COPD Phenotypes and Disease ProgressionR44HL118837 · NHLBI · IMBIO, LLC · PI GALBAN, CRAIG J, HATT, CHARLES R · 2013 to 2016
$1.8M
NCI NIH HHS P01 CA085878NCI NIH HHS R35 CA197701NHLBI NIH HHS R01 HL094622NHLBI NIH HHS R01 HL118017NHLBI NIH HHS R01 HL122438NHLBI NIH HHS R44 HL118837
6 · The paper itself

Abstract

rationaleThe predominant cause of chronic lung allograft failure is small airway obstruction arising from bronchiolitis obliterans. However, clinical methodologies for evaluating presence and degree of small airway disease are lacking.

objectivesTo determine if parametric response mapping (PRM), a novel computed tomography voxel-wise methodology, can offer insight into chronic allograft failure phenotypes and provide prognostic information following spirometric decline.

methodsPRM-based computed tomography metrics quantifying functional small airways disease (PRM MEASUREMENTS AND MAIN

resultsPatients presenting with an isolated decline in FEV

conclusionsPRM is a novel imaging tool for lung transplant recipients presenting with spirometric decline. Quantifying underlying small airway obstruction via PRM

Indexed as

Lung TransplantationAdultAirway ObstructionBiomarkersCohort StudiesFemaleForced Expiratory VolumeGraft RejectionHumansImage Processing, Computer-AssistedLungMaleMiddle AgedReproducibility of ResultsTomography, X-Ray ComputedTransplant RecipientsBiomarkersbronchiolitis obliterans syndromechronic lung allograft dysfunctioncomputed tomography of the chestparametric response mappingprognosis

Identifiers

PMID27779421
PMCPMC5387704
OpenAlexW2534071065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.