ArticleEuropean journal of neurology2017
SORL1 rs1699102 polymorphism modulates age-related cognitive decline and gray matter volume reduction in non-demented individuals.
Article in European journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Heritability of cognitive abilities and regional brain structures in middle-aged to elderly East Asians.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation.Frontiers in human neuroscience · 2023Article
- Endophenotypic effects of theFrontiers in aging neuroscience · 2022Article
- Genetic Insights into Alzheimer's Disease.Annual review of pathology · 2021Review
- Case report of first-episode psychotic symptoms in a patient with early-onset Alzheimer's disease.BMC psychiatry · 2020Article
- The neuroprotective role of melatonin in neurological disorders.Journal of neuroscience research · 2018Review
- [Verification of a sporadic Alzheimer disease model in SORL1 gene knockout mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- The role of melatonin in the onset and progression of type 3 diabetes.Molecular brain · 2017Review
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
background and purposeSORL1 rs1699102 is associated with the risk of late-onset Alzheimer's disease. However, the effects of this single nucleotide polymorphism on cognition and brain structure during normal aging are unclear. This study aimed to examine the effects of the rs1699102 polymorphism on age-related cognitive decline and cortical gray matter reduction in the Chinese Han population.
methodsA total of 780 non-demented adults completed a battery of neuropsychological tests. High-resolution T1-weighted structural magnetic resonance imaging data from 89 of these subjects were also collected using a Siemens Trio 3.0 Tesla scanner.
resultsThe T allele carriers displayed an accelerated age-related change in episodic memory and processing speed tests relative to the CC genotype. A similar pattern was observed in the age-related gray matter volume (GMV) reduction of the right middle temporal pole. The GMV in this region was significantly positively correlated with the episodic memory scores.
conclusionsThe SORL1 gene rs1699102 polymorphism has been found to be associated with age-related cognitive decline and GMV reduction of the right middle temporal pole in older adults. These findings elucidate how the SORL1 variants shape the neural system to modulate age-related cognitive decline and support the hypothesis that SORL1 may represent a candidate gene for late-onset Alzheimer's disease.
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