ArticleScientific reports2016
Brain white matter plasticity and functional reorganization underlying the central pathogenesis of trigeminal neuralgia.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Migraine is Related to Multiple Sclerosis Brain Lesions in the Central Pain Network with Several Migraine Phenotypes Exhibiting Different Lesion Patterns.Brain topography · 2026Article
- Fixel‑based analysis reveals distributed white matter alterations associated with pain severity in trigeminal neuralgia.The journal of headache and pain · 2026Article
- Subcortical neuroimaging signature of painful disorders of the trigeminal nerve: a UK Biobank study.The journal of headache and pain · 2026Article
- Reduced volume in the amygdala of trigeminal neuralgia patients: a neuroimaging study with clinical correlates.Experimental brain research · 2025Article
- Disruption of functional and structural topological organization in specific subnetwork among patients with classical trigeminal neuralgia: a graph theory-based magnetic resonance imaging study.Brain imaging and behavior · 2025Article
- Alteration in functional connectivity of SC_thalamus with primary trigeminal neuralgia.BMC neurology · 2025Article
- Article
- Cerebral lesions in the central pain matrix are associated with headache in multiple sclerosis.Scientific reports · 2025Article
- Analyzing the relationship between specific brain structural changes and the diffusion tensor image analysis along the perivascular space index in idiopathic normal pressure hydrocephalus.Journal of neurology · 2024Article
- Phenotyping Pain in Patients With Fibrous Dysplasia/McCune-Albright Syndrome.The Journal of clinical endocrinology and metabolism · 2024Article
- The white matter characteristic of the genu of corpus callosum coupled with pain intensity and negative emotion scores in patients with trigeminal neuralgia: a multivariate analysis.Frontiers in neuroscience · 2024Article
- Diffusion tensor and kurtosis imaging reveal microstructural changes in the trigeminal nerves of patients with trigeminal neuralgia.European radiology · 2023Article
- Imaging the neural substrate of trigeminal neuralgia pain using deep learning.Frontiers in human neuroscience · 2023Article
- Experience-dependent associations between distinct subtypes of childhood trauma and brain function and architecture.Quantitative imaging in medicine and surgery · 2022Article
- Gray matter volume reduction with different disease duration in trigeminal neuralgia.Neuroradiology · 2022Article
- White Matter Diffusion Properties in Chronic Temporomandibular Disorders: An Exploratory Analysis.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Altered Structural and Functional Abnormalities of Hippocampus in Classical Trigeminal Neuralgia: A Combination of DTI and fMRI Study.Journal of healthcare engineering · 2022Article
- Distal neuropathic pain in HIV is associated with functional connectivity patterns in default mode and salience networks.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Resveratrol Ameliorates Trigeminal Neuralgia-Induced Cognitive Deficits by Regulating Neural Ultrastructural Remodelling and the CREB/BDNF Pathway in Rats.Oxidative medicine and cellular longevity · 2022Article
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8 authors.
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Abstract
Peripheral nerve damage does not fully explain the pathogenesis of trigeminal neuralgia (TN). Central nervous system changes can follow trigeminal nerve dysfunction. We hypothesized that brain white matter and functional connectivity changes in TN patients were involved in pain perception, modulation, the cognitive-affective system, and motor function; moreover, changes in functional reorganization were correlated with white matter alterations. Twenty left TN patients and twenty-two healthy controls were studied. Diffusion kurtosis imaging was analyzed to extract diffusion and kurtosis parameters, and functional connectivity density (FCD) mapping was used to explore the functional reorganization in the brain. In the patient group, we found lower axial kurtosis and higher axial diffusivity in tracts participated in sensory, cognitive-affective, and modulatory aspects of pain, such as the corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, cingulated gyrus, forceps major and uncinate fasciculus. Patients exhibited complex FCD reorganization of hippocampus, striatum, thalamus, precentral gyrus, precuneus, prefrontal cortex and inferior parietal lobule in multiple modulatory networks that played crucial roles in pain perception, modulation, cognitive-affective system, and motor function. Further, the correlated structural-functional changes may be responsible for the persistence of long-term recurrent pain and sensory-related dysfunction in TN.
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