ReviewThe pharmacogenomics journal2017
Pharmacogenomic implications of the evolutionary history of infectious diseases in Africa.
Review in The pharmacogenomics journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Evidence for Pathogen-Driven Selection Acting onEcology and evolution · 2025Article
- Bridging genomics' greatest challenge: The diversity gap.Cell genomics · 2025Review
- Towards pharmacogenomics-guided tuberculosis (TB) therapy: N-acetyltransferase-2 genotypes among TB-infected Kenyans of mixed ethnicity.BMC medical genomics · 2024Article
- Phenotypes, endotypes and genotypes of atopic dermatitis and allergy in populations of African ancestry on the continent and diaspora.Frontiers in allergy · 2023Review
- Assessment of the Availability and Accuracy of Dosing Devices Packaged with Oral Liquid Medications in the Ho Municipality of Ghana.Scientifica · 2022Article
- Individualized Medicine in Africa: Bringing the Practice Into the Realms of Population Heterogeneity.Frontiers in genetics · 2022Article
- Evolutionary genetics and acclimatization in nephrology.Nature reviews. Nephrology · 2021Review
- When silence goes viral, Africa sneezes! A perspective on Africa's subdued research response to COVID-19 and a call for local scientific evidence.Environmental research · 2021Article
- Common Treatment, Common Variant: Evolutionary Prediction of Functional Pharmacogenomic Variants.Journal of personalized medicine · 2021Article
- Precision Medicine in Control of Visceral Leishmaniasis Caused byFrontiers in cellular and infection microbiology · 2021Review
- Evaluating the promise of inclusion of African ancestry populations in genomics.NPJ genomic medicine · 2020Review
- Article
- Estimated glomerular filtration rate predicts incident stroke among Ghanaians with diabetes and hypertension.Journal of the neurological sciences · 2019Article
- The Emergence of Genomic Research in Africa and New Frameworks for Equity in Biomedical Research.Ethnicity & disease · 2019Article
- Whole-Exome Sequencing Reveals Uncaptured Variation and Distinct Ancestry in the Southern African Population of Botswana.American journal of human genetics · 2018Article
- APOL1, CDKN2A/CDKN2B, and HDAC9 polymorphisms and small vessel ischemic stroke.Acta neurologica Scandinavica · 2018Article
- The genomic landscape of African populations in health and disease.Human molecular genetics · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
As the common birthplace of all human populations, modern humans have lived longer on the African continent than in any other geographical region of the world. This long history, along with the evolutionary need to adapt to environmental challenges such as exposure to infectious agents, has led to greater genetic variation in Africans. The vast genetic variation in Africans also extends to genes involved in the absorption, distribution, metabolism and excretion of pharmaceuticals. Ongoing cataloging of these clinically relevant variants reveals huge allele-frequency differences within and between African populations. Here, we examine Africa's large burden of infectious disease, discuss key examples of known genetic variation modulating disease risk, and provide examples of clinically relevant variants critical for establishing dosing guidelines. We propose that a more systematic characterization of the genetic diversity of African ancestry populations is required if the current benefits of precision medicine are to be extended to these populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.