Evidence map›Paper›PMID 27779240›Full record

ArticleScientific reports2016

Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies.

Fang Zheng, Harris Perlman, Patrick Matthys, Yurong Wen, Tony Lahoutte, Serge Muyldermans, Shemin Lu, Patrick De Baetselier, Steve Schoonooghe, Nick Devoogdt and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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  9. Antibody-Based Tracers for PET/SPECT Imaging of Chronic Inflammatory Diseases.Chembiochem : a European journal of chemical biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Fang ZhengDepartment of Biochemistry and Molecular Biology, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P. R. China.
Harris PerlmanDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL60611, USA.
Patrick MatthysLaboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, B-3000, Belgium.
Yurong WenCenter for Translational Medicine, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
Tony LahoutteIn Vivo Cellular and Molecular Imaging Center, Vrije Universiteit Brussel, Brussels, B-1090, Belgium.
Serge MuyldermansResearch group of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, B-1050, Belgium.
Shemin LuDepartment of Biochemistry and Molecular Biology, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P. R. China.
Patrick De BaetselierResearch group of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, B-1050, Belgium.
Steve SchoonoogheResearch group of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, B-1050, Belgium.
Nick DevoogdtResearch group of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, B-1050, Belgium.
Geert RaesResearch group of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, B-1050, Belgium.
Vrije Universiteit Brussel · BEXi'an Jiaotong University · CNVIB-UGent Center for Inflammation Research · BENorthwestern University · USRega Institute for Medical Research · BE

Funding

Development of a Novel RA/Atherosclerosis Mouse ModelR01AR064546 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PERLMAN, HARRIS R · 2013 to 2017
$1.6M
NIAMS NIH HHS R01 AR064546
6 · The paper itself

Abstract

Single-photon emission computed tomography combined with micro-CT (SPECT/μCT) imaging using Nanobodies against complement receptor of the Ig superfamily (CRIg), found on tissue macrophages such as synovial macrophages, has promising potential to visualize joint inflammation in experimental arthritis. Here, we further addressed the specificity and assessed the potential for arthritis monitoring. Signals obtained with

Indexed as

AnimalsArthritisDisease Models, AnimalMiceReceptors, ComplementSensitivity and SpecificitySingle-Domain AntibodiesSingle Photon Emission Computed Tomography Computed TomographyReceptors, ComplementSingle-Domain Antibodies

Identifiers

PMID27779240
PMCPMC5078791
OpenAlexW2533316464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.