Evidence map›Paper›PMID 27779232›Full record

ArticleScientific reports2016

Network Consistency Projection for Human miRNA-Disease Associations Inference.

Changlong Gu, Bo Liao, Xiaoying Li, Keqin Li

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Changlong GuCollege of Information Science and Engineering, Hunan University, Changsha, Hunan 410082, China.
Bo LiaoCollege of Information Science and Engineering, Hunan University, Changsha, Hunan 410082, China.
Xiaoying LiCollege of Information Science and Engineering, Hunan University, Changsha, Hunan 410082, China.
Keqin LiDepartment of Computer Science, State University of New York, New Paltz, New York 12561, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prediction and confirmation of the presence of disease-related miRNAs is beneficial to understand disease mechanisms at the miRNA level. However, the use of experimental verification to identify disease-related miRNAs is expensive and time-consuming. Effective computational approaches used to predict miRNA-disease associations are highly specific. In this study, we develop the Network Consistency Projection for miRNA-Disease Associations (NCPMDA) method to reveal the potential associations between miRNAs and diseases. NCPMDA is a non-parametric universal network-based method that can simultaneously predict miRNA-disease associations in all diseases but does not require negative samples. NCPMDA can also confirm the presence of miRNAs in isolated diseases (diseases without any known miRNA association). Leave-one-out cross validation and case studies have shown that the predictive performance of NCPMDA is superior over that of previous method.

Indexed as

Genetic Predisposition to DiseaseAlgorithmsBreast NeoplasmsCarcinoma, HepatocellularComputational BiologyGenetic Association StudiesHumansLiver NeoplasmsMicroRNAsRNA, MessengerMicroRNAsRNA, Messenger

Identifiers

PMID27779232
PMCPMC5078764

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.