ArticleScientific reports2016
Form, shape and function: segmented blood flow in the choriocapillaris.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 61 citations in OpenAlex.
- Matrix metalloproteinase-mediated degradation governs angioarchitecture within poly(ethylene Glycol) hydrogels.Acta biomaterialia · 2026Article
- Macular Choriocapillaris and Retinal Microvascular Alterations Across the Prediabetes-Early Type 2 Diabetes Continuum.Investigative ophthalmology & visual science · 2026Article
- Analysis of the therapeutic effects of anti-vascular endothelial growth factor treatment based on indocyanine green angiographic staining patterns in patients with central serous chorioretinopathy.Indian journal of ophthalmology · 2026Article
- Choriocapillaris Flow Signal Deficits Are Associated With AMD Onset and Early Progression Over Three Years: ALSTAR2 Follow-Up.Investigative ophthalmology & visual science · 2026Article
- Endothelial-to-mesenchymal transition in the central nervous system: A potential therapeutic target to combat age-related vascular fragility.The Journal of pharmacology and experimental therapeutics · 2025Review
- Quantification of Normative Human Choriocapillaris Measures Across the Macula.Investigative ophthalmology & visual science · 2025Article
- Flow and ischemic changes in retina and choroid across diabetic retinopathy spectrum: a SS-OCTA study.Eye (London, England) · 2025Observational
- Choriocapillaris Impairment, Visual Function, and Distance to Fovea in Aging and Age-Related Macular Degeneration: ALSTAR2 Baseline.Investigative ophthalmology & visual science · 2024Article
- The vascular geometry of the choriocapillaris is associated with spatially heterogeneous molecular exchange with the outer retina.The Journal of physiology · 2024Article
- Ocular microvascular complications in diabetic retinopathy: insights from machine learning.BMJ open diabetes research & care · 2024Article
- "Energetics of the outer retina I: Estimates of nutrient exchange and ATP generation".PloS one · 2024Article
- Effects of donor-specific microvascular anatomy on hemodynamic perfusion in human choriocapillaris.Scientific reports · 2023Article
- Ex vivo ocular perfusion model to study vascular physiology in the mouse eye.Experimental eye research · 2023Article
- Effects of physiological fluctuations on the estimation of vascular flow in eyes with idiopathic macular pucker.Eye (London, England) · 2023Article
- Oxidative Stress Induced Dysfunction of Protein Synthesis in 661W Mice Photoreceptor Cells.Proteomes · 2023Article
- Polyunsaturated Lipids in the Light-Exposed and Prooxidant Retinal Environment.Antioxidants (Basel, Switzerland) · 2023Review
- Article
- Choroidal arteriovenous anastomoses: a hypothesis for the pathogenesis of central serous chorioretinopathy and other pachychoroid disease spectrum abnormalities.Acta ophthalmologica · 2022Article
- Angiopoietin-1 Is Required for Vortex Vein and Choriocapillaris Development in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex.BMC ophthalmology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of fluid transport systems was a key event in the evolution of animals and plants. While within vertebrates branched geometries predominate, the choriocapillaris, which is the microvascular bed that is responsible for the maintenance of the outer retina, has evolved a planar topology. Here we examine the flow and mass transfer properties associated with this unusual geometry. We show that as a result of the form of the choriocapillaris, the blood flow is decomposed into a tessellation of functional vascular segments of various shapes delineated by separation surfaces across which there is no flow, and in the vicinity of which the transport of passive substances is diffusion-limited. The shape of each functional segment is determined by the distribution of arterioles and venules and their respective relative flow rates. We also show that, remarkably, the mass exchange with the outer retina is a function of the shape of each functional segment. In addition to introducing a novel framework in which the structure and function of the metabolite delivery system to the outer retina may be investigated in health and disease, the present work provides a general characterisation of the flow and transfers in multipole Hele-Shaw configurations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.