ArticleNature communications2016
Microtubule organization is determined by the shape of epithelial cells.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- From Pixels to Patterns: A Multidimensional Framework to Decode Cytoskeletal Organization.Computational and structural biotechnology journal · 2026Review
- Article
- Microtubule-based nucleation results in a large sensitivity to cell geometry of the plant cortical array.PLoS computational biology · 2025Article
- Single-dose cathepsin L CRISPR nanotherapy mitigates PASC-like lung damage in hamsters.Nano research · 2025Article
- Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation.Nature communications · 2025Article
- Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the earlyeLife · 2024Article
- Dynamic interplay of microtubule and actomyosin forces drive tissue extension.Nature communications · 2024Article
- Deciphering the roles of cell shape and Fat and Dachsous planar polarity in arranging theMolecular biology of the cell · 2023Article
- High-resolution line-scan Brillouin microscopy for live imaging of mechanical properties during embryo development.Nature methods · 2023Article
- Superresolution microscopy reveals actomyosin dynamics in medioapical arrays.Molecular biology of the cell · 2022Article
- Multiple asters organize the yolk microtubule network during dclk2-GFP zebrafish epiboly.Scientific reports · 2022Article
- The Lateral Epidermis Actively Counteracts Pulling by the Amnioserosa During Dorsal Closure.Frontiers in cell and developmental biology · 2022Article
- Crosstalk between basal extracellular matrix adhesion and building of apical architecture during morphogenesis.Biology open · 2021Review
- Automated and unbiased discrimination of ALS from control tissue at single cell resolution.Brain pathology (Zurich, Switzerland) · 2021Article
- Article
- How do the Fat-Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours?Open biology · 2021Review
- Planar cell polarity in the larval epidermis ofOpen biology · 2020Article
- Cytoskeletal organization in isolated plant cells under geometry control.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Actin-microtubule crosstalk in cell biology.Nature reviews. Molecular cell biology · 2019Review
- Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis.Nature cell biology · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Interphase microtubule organization is critical for cell function and tissue architecture. In general, physical mechanisms are sufficient to drive microtubule organization in single cells, whereas cells within tissues are thought to utilize signalling mechanisms. By improving the imaging and quantitation of microtubule alignment within developing Drosophila embryos, here we demonstrate that microtubule alignment underneath the apical surface of epithelial cells follows cell shape. During development, epidermal cell elongation and microtubule alignment occur simultaneously, but by perturbing cell shape, we discover that microtubule organization responds to cell shape, rather than the converse. A simple set of microtubule behaviour rules is sufficient for a computer model to mimic the observed responses to changes in cell surface geometry. Moreover, we show that microtubules colliding with cell boundaries zip-up or depolymerize in an angle-dependent manner, as predicted by the model. Finally, we show microtubule alignment responds to cell shape in diverse epithelia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.