Evidence map›Paper›PMID 27778641›Full record

ArticleThe Journal of clinical endocrinology and metabolism2017

Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4.

Niraj R Joshi, Eduardo H Miyadahira, Yalda Afshar, Jae-Wook Jeong, Steven L Young, Bruce A Lessey, Paulo C Serafini, Asgerally T Fazleabas

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. MiR-29c-3p Impairs the Adhesion of Endometrial Epithelial Cells via COL4A1/β-catenin in Endometriosis.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Niraj R JoshiDepartment of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan 49503.
Eduardo H MiyadahiraHuntigton Medicina Reprodutiva, São Paulo 04021-000, Brazil.
Yalda AfsharDepartment of Obstetrics and Gynecology, University of California, Los Angeles, California 90095.
Jae-Wook JeongDepartment of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan 49503.
Steven L YoungDepartment of Obstetrics and Gynecology, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599.
Bruce A LesseyGreenville Hospital System, University of South Carolina School of Medicine, Greenville, South Carolina 29605; and.
Paulo C SerafiniDiscipline of Gynecology, Department of Obstetrics and Gynecology, Hospital das clinicas, faculdade de Medicina, Universidade de São Paulo, São Paulo 01246-903, Brazil.
Asgerally T FazleabasDepartment of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan 49503.
Michigan State University · USInstituto Tropical de Medicina Reprodutiva · BRUniversity of California, Los Angeles · USUniversity of North Carolina at Chapel Hill · USUniversity of South Carolina · US

Funding

Progesterone Action in the Endometrium of Women with EndometriosisR01HD067721 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YOUNG, STEVEN L · 2011 to 2015
$3.1M
Role of microRNA in the Pathophysiology of EndometriosisR01HD083273 · NICHD · MICHIGAN STATE UNIVERSITY · PI FAZLEABAS, ASGERALLY T. · 2016 to 2020
$1.8M
NICHD NIH HHS R01 HD067721NICHD NIH HHS R01 HD083273
6 · The paper itself

Abstract

Context: Endometriosis results in aberrant gene expression in the eutopic endometrium (EuE) and subsequent progesterone resistance. MicroRNA (miR) microarray data in a baboon model of endometriosis showed an increased expression of miR-29c. Objectives: To explore the role of miR-29c in progesterone resistance in a subset of women with endometriosis. Design: MiR-29c expression was analyzed in the endometrium of baboons and women with or without endometriosis. The role in progesterone resistance and decidualization was analyzed by transfecting human uterine fibroblast cells with miR-29c. Patients: Subjects diagnosed with deep infiltrative endometriosis (DIE) by transvaginal ultrasound with bowel preparation underwent surgical excision of endometriosis. Eutopic secretory endometrium was collected pre- and postoperatively. Women with normal EuE and without DIE served as controls. Results: Quantitative reverse transcription polymerase chain reaction demonstrated that miR-29c expression increased, while the transcript levels of its target, FK506-binding protein 4 (FKBP4), decreased in the EuE of baboons following the induction of endometriosis. FKBP4 messenger RNA and decidual markers were statistically significantly decreased in decidualized human uterine fibroblast cells transfected with a miR-29c mimic compared with controls. Human data corroborated our baboon data and demonstrated higher expression of miR-29c in endometriosis EuE compared with normal EuE. MiR-29c was significantly decreased in endometriosis EuE postoperatively compared with preoperative tissues, and FKBP4 showed an inverse trend following radical laparoscopic resection surgery. Conclusions: We demonstrate that miR-29c expression is increased in EuE of baboons and women with endometriosis, which might contribute to a compromised progesterone response by diminishing the levels of FKBP4. Resection of DIE is likely to reverse the progesterone resistance associated with endometriosis in women.

Indexed as

AnimalsBiomarkersCase-Control StudiesDisease Models, AnimalEndometriosisEndometriumFemaleHumansMicroRNAsPapioProgesteronePrognosisTacrolimus Binding ProteinsUterine DiseasesBiomarkersMicroRNAsMIRN29a microRNA, humanProgesteronetacrolimus binding protein 4Tacrolimus Binding Proteins

Identifiers

PMID27778641
PMCPMC5413101
OpenAlexW2534032587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.