ArticleInternational journal of cancer2017
Periodontal disease, tooth loss and colorectal cancer risk: Results from the Nurses' Health Study.
Article in International journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 87 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of a Daily Oral Care Lozenge on Oral Health and Quality of Life in Older Adults
PROSpECT-PRIOR-2-CHEMO: A Feasibility RCT of Novel Dental Intervention PRIOR[Proactive Intensive Oral Review & Treatment] in Patients Scheduled for Chemotherapy for Myeloma-ASCT & Hematological Cancers to Mitigate Chemotherapy Complications
Who cites it
87 citing papers in PubMed, 6 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Periodontal Disease and Incidence of Cancers: A Systematic Review and Meta-analysis of Cohort Studies.International dental journal · 2026Pooled it
- Associations of oral health with colorectal cancer risk: accumulated evidences from observational studies.BMC cancer · 2026Pooled it
- Periodontitis as a risk factor for colorectal cancer: systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2025Pooled it
- Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies.Acta odontologica Scandinavica · 2024Pooled it
- Pooled it
- Pooled it
- Human salivary microbiome as a potential non-invasive biomarker for early-onset colorectal cancer screening: a prospective study.BMC microbiology · 2026Article
- Cancer Therapy Using Antiparasitic Medications Guided by Acupuncture Meridian Assessment: A Case Series of Six Patients.Integrative medicine (Encinitas, Calif.) · 2026Article
- Article
- Clinical Profile, Risk Factors, and Microbial Dysbiosis in Periodontitis: Findings from an Adult Cohort and Microbiome-Based Predictive Models.Journal of clinical medicine · 2026Article
- Increased Production of Angiopoietin-like Protein 2 in a Ligature- and LPS-Induced Periodontitis Mouse Model May Promote Colorectal Tumor Progression.Journal of clinical medicine · 2026Article
- Cost-Effectiveness of promoting preventive oral self-care in China: a population-based modelling study.BMJ public health · 2026Article
- The oral - X axis: from periodontal dysbiosis to systemic disease.Frontiers in immunology · 2026Review
- Periodontitis, colorectal cancer and associated factors: A cross-sectional study.Journal of clinical and experimental dentistry · 2026Review
- Periodontitis and Oral Pathogens in Colorectal Cancer: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.Dentistry journal · 2025Review
- Bridging oral and systemic health: exploring pathogenesis, biomarkers, and diagnostic innovations in periodontal disease.Infection · 2025Review
- Immunoinflammatory Mechanisms Connecting Periodontitis and Solid Tumors: A Systematic Review of Original Evidence.Cureus · 2025Review
- Red Complex Periodontal Pathogens and Their Potential Role in Colorectal Carcinogenesis: A Narrative Review.International journal of molecular sciences · 2025Review
- Oral microbiota signature predicts the prognosis of colorectal carcinoma.NPJ biofilms and microbiomes · 2025Article
- The human oral microbiome and risk of colorectal cancer within three prospective cohort studies in the United States.Cancer · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 1 country.
Funding
Abstract
Periodontal diseases including tooth loss might increase systemic inflammation, lead to immune dysregulation and alter gut microbiota, thereby possibly influencing colorectal carcinogenesis. Few epidemiological studies have examined the association between periodontal diseases and colorectal cancer (CRC) risk. We collected information on the periodontal disease (defined as history of periodontal bone loss) and number of natural teeth in the Nurses' Health Study. A total of 77,443 women were followed since 1992. We used Cox proportional hazard models to calculate multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) after adjustment for smoking and other known risk factors for CRC. We documented 1,165 incident CRC through 2010. Compared to women with 25-32 teeth, the multivariable HR (95% CI) for CRC for women with <17 teeth was 1.20 (1.04-1.39). With regard to tumor site, the HRs (95% CIs) for the same comparison were 1.23 (1.01-1.51) for proximal colon cancer, 1.03 (0.76-1.38) for distal colon cancer and 1.48 (1.07-2.05) for rectal cancer. In addition, compared to those without periodontal disease, HRs for CRC were 0.91 (95% CI 0.74-1.12) for periodontal disease, and 1.22 (95% CI 0.91-1.63) when limited to moderate to severe periodontal disease. The results were not modified by smoking status, body mass index or alcohol consumption. Women with fewer teeth, possibly moderate or severe periodontal disease, might be at a modest increased risk of developing CRC, suggesting a potential role of oral health in colorectal carcinogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.