Evidence map›Paper›PMID 27778308›Full record

ReviewMolecular and cellular pediatrics2016

Leukocyte recruitment in preterm and term infants.

Katinka Karenberg, Hannes Hudalla, David Frommhold

Open access · goldAbstract readReview
In one paragraph

Review in Molecular and cellular pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Katinka KarenbergDepartment of Neonatology, University Children's Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
Hannes HudallaDepartment of Neonatology, University Children's Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
David FrommholdDepartment of Neonatology, University Children's Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany. David.Frommhold@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-7289-1346
Heidelberg University · DEBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired cellular innate immune defense accounts for susceptibility to sepsis and its high morbidity and mortality in preterm infants. Leukocyte recruitment is an integral part of the cellular immune response and follows a well-defined cascade of events from rolling of leukocytes along the endothelium to firm adhesion and finally transmigration which is concerted by a variety of adhesion molecules. Recent analytical advances such as fetal intravital microscopy have granted new insights into ontogenetic regulation and maturation of fetal immune cell recruitment. Understanding the fetal innate immune system is essential for targeted prevention and therapy of premature infants with severe infections or disorders of the immune system. This review gives an overview of the basic principles of leukocyte recruitment, particularly neutrophil trafficking, and its development during early life and highlights technical limitations to our current knowledge.

Indexed as

AdhesionFetusInnate immunityLeukocyte recruitmentNeutrophilNewbornPretermRollingSepsisTransmigration

Identifiers

PMID27778308
PMCPMC5078115
OpenAlexW2539071828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.