Evidence map›Paper›PMID 27778257›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2017

Preoperative Therapy and Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma: a 25-Year Single-Institution Experience.

Jordan M Cloyd, Matthew H G Katz, Laura Prakash, Gauri R Varadhachary, Robert A Wolff, Rachna T Shroff, Milind Javle, David Fogelman, Michael Overman, Christopher H Crane and 20 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 139 citations in OpenAlex.

  1. Patient experience and quality of life during neoadjuvant therapy for pancreatic cancer: a systematic review and study protocol.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 4 institutions in 2 countries.

Jordan M CloydDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1400 Pressler St, Unit 1484, Houston, TX, 77030, USA.
Matthew H G KatzDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1400 Pressler St, Unit 1484, Houston, TX, 77030, USA.
Laura PrakashDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1400 Pressler St, Unit 1484, Houston, TX, 77030, USA.
Gauri R VaradhacharyDepartment of Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Robert A WolffDepartment of Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Rachna T ShroffDepartment of Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Milind JavleDepartment of Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
David FogelmanDepartment of Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Michael OvermanDepartment of Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Christopher H CraneDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Eugene J KoayDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Prajnan DasDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sunil KrishnanDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bruce D MinskyDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jeffrey H LeeDepartment of Gasteroenterology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Manoop S BhutaniDepartment of Gasteroenterology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Brian WestonDepartment of Gasteroenterology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
William RossDepartment of Gasteroenterology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Priya BhosaleDepartment of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Eric P TammDepartment of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Huamin WangDepartment of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Anirban MaitraDepartment of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Michael P KimDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1400 Pressler St, Unit 1484, Houston, TX, 77030, USA.
Thomas A AloiaDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1400 Pressler St, Unit 1484, Houston, TX, 77030, USA.
Jean-Nicholas VautheyDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1400 Pressler St, Unit 1484, Houston, TX, 77030, USA.
Jason B FlemingDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1400 Pressler St, Unit 1484, Houston, TX, 77030, USA.
James L AbbruzzeseDivision of Medical Oncology, Department of Medicine, Duke University, Durham, NC, USA.
Peter W T PistersUniversity Health Network, Toronto, ON, Canada.
Douglas B EvansDivision of Surgical Oncology, Department of Surgery, The Medical College of Wisconsin, Milwaukee, WI, USA.
Jeffrey E LeeDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1400 Pressler St, Unit 1484, Houston, TX, 77030, USA. jelee@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USDuke Medical Center · USMedical College of Wisconsin · USUniversity Health Network · CA

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
6 · The paper itself

Abstract

backgroundThe purpose of this study was to evaluate a single-institution experience with delivery of preoperative therapy to patients with pancreatic ductal adenocarcinoma (PDAC) prior to pancreatoduodenectomy (PD).

methodsConsecutive patients (622) with PDAC who underwent PD following chemotherapy and/or chemoradiation between 1990 and 2014 were retrospectively reviewed. Preoperative treatment regimens, clinicopathologic characteristics, operative details, and long-term outcomes in four successive time periods (1990-1999, 2000-2004, 2005-2009, 2010-2014) were evaluated and compared.

resultsThe average number of patients per year who underwent PD following preoperative therapy as well as the proportion of operations performed for borderline resectable and locally advanced (BR/LA) tumors increased over time. The use of induction systemic chemotherapy, as well as postoperative adjuvant chemotherapy, also increased over time. Throughout the study period, the mean EBL decreased while R0 margin rates and vascular resection rates increased overall. Despite the increase in BR/LA resections, locoregional recurrence (LR) rates remained similar over time, and overall survival (OS) improved significantly (median 24.1, 28.1, 37.3, 43.4 months, respectively, p < 0.0001).

conclusionsDespite increases in case complexity, relatively low rates of LR have been maintained while significant improvements in OS have been observed. Further improvements in patient outcomes will likely require disruptive advances in systemic therapy.

Indexed as

Neoadjuvant TherapyPancreaticoduodenectomyPreoperative CareAdenocarcinomaCarcinoma, Pancreatic DuctalChemoradiotherapyChemotherapy, AdjuvantFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalPancreatic NeoplasmsRetrospective StudiesNeoadjuvant therapyPancreatectomyPancreatic ductal adenocarcinomaPancreatoduodenectomy

Identifiers

PMID27778257
OpenAlexW2536439468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.