Evidence map›Paper›PMID 27778226›Full record

ArticleBiomedical microdevices2016

In vitro clearance of doxorubicin with a DNA-based filtration device designed for intravascular use with intra-arterial chemotherapy.

Mariam S Aboian, Jay F Yu, Ayushi Gautam, Chia-Hung Sze, Jeffrey K Yang, Jonathan Chan, Prasheel V Lillaney, Caroline D Jordan, Hee-Jeung Oh, David M Wilson and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical microdevices, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. 3D Printed Biosponge Adsorbers for Capturing Toxic Chemotherapy DrugsACS biomaterials science & engineering · 2026
    Article
  3. Article
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  10. A two-scale approach for CFD modeling of endovascular Chemofilter device.Biomechanics and modeling in mechanobiology · 2018
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Mariam S AboianDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Room 320, San Francisco, CA, 94107-5705, USA.
Jay F YuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Room 320, San Francisco, CA, 94107-5705, USA.
Ayushi GautamDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Room 320, San Francisco, CA, 94107-5705, USA.
Chia-Hung SzeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Room 320, San Francisco, CA, 94107-5705, USA.
Jeffrey K YangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Room 320, San Francisco, CA, 94107-5705, USA.
Jonathan ChanDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Room 320, San Francisco, CA, 94107-5705, USA.
Prasheel V LillaneyDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Room 320, San Francisco, CA, 94107-5705, USA.
Caroline D JordanDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Room 320, San Francisco, CA, 94107-5705, USA.
Hee-Jeung OhDepartment of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, 94720, USA.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Room 320, San Francisco, CA, 94107-5705, USA.
Anand S PatelDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Room 320, San Francisco, CA, 94107-5705, USA.
Mark W WilsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Room 320, San Francisco, CA, 94107-5705, USA.
Steven W HettsDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Room 320, San Francisco, CA, 94107-5705, USA. steven.hetts@ucsf.edu.
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

Biomedical Imaging for Clinician ScientistsT32EB001631 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THOMAS M LINK · 2005 to 2026
$5.6M
Endovascular Chemofiltration: Optimizing Removal of Chemotherapeutics and Nanoparticles from the Blood to Reduce ToxicityR01CA194533 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HETTS, STEVEN WILLIAM · 2015 to 2019
$2.6M
ChemoFilter: A Novel Catheter Device to Enable High-Dose Chemotherapy TreatmentR41CA183327 · NCI · CHEMOFILTER, INC. · PI PATEL, ANAND S · 2014 to 2014
$225k
NCI NIH HHS R01 CA194533NCI NIH HHS R41 CA183327NIBIB NIH HHS T32 EB001631
6 · The paper itself

Abstract

To report a novel method using immobilized DNA within mesh to sequester drugs that have intrinsic DNA binding characteristics directly from flowing blood. DNA binding experiments were carried out in vitro with doxorubicin in saline (PBS solution), porcine serum, and porcine blood. Genomic DNA was used to identify the concentration of DNA that shows optimum binding clearance of doxorubicin from solution. Doxorubicin binding kinetics by DNA enclosed within porous mesh bags was evaluated. Flow model simulating blood flow in the inferior vena cava was used to determine in vitro binding kinetics between doxorubicin and DNA. The kinetics of doxorubicin binding to free DNA is dose-dependent and rapid, with 82-96 % decrease in drug concentration from physiologic solutions within 1 min of reaction time. DNA demonstrates faster binding kinetics by doxorubicin as compared to polystyrene resins that use an ion exchange mechanism. DNA contained within mesh yields an approximately 70 % decrease in doxorubicin concentration from solution within 5 min. In the IVC flow model, there is a 70 % drop in doxorubicin concentration at 60 min. A DNA-containing ChemoFilter device can rapidly clear clinical doses of doxorubicin from a flow model in simple and complex physiological solutions, thereby suggesting a novel approach to reduce the toxicity of DNA-binding drugs.

Indexed as

ArteriesAnimalsDNADoxorubicinEquipment DesignFeasibility StudiesFiltrationKineticsSwineDNADoxorubicinChemotherapyDetoxificationEndovascular devices

Identifiers

PMID27778226
PMCPMC5441460
OpenAlexW2533872688

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.