ArticleDigestive diseases and sciences2017
Rates and Predictors of Endoscopic and Clinical Recurrence After Primary Ileocolic Resection for Crohn's Disease.
Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relationship Between Endoscopic and Clinical Recurrence in Postoperative Crohn's Disease: A Systematic Review and Meta-analysis.Journal of Crohn's & colitis · 2022Pooled it
- Ileocolic resection versus medical therapy for Crohn's disease in the post-biologic era: a systematic review.Translational gastroenterology and hepatology · 2026Review
- Postoperative Recurrence in Crohn's Disease: Pathophysiology, Risk Stratification, and Management Strategies.Journal of clinical medicine · 2025Review
- Small bowel pyloric metaplasia is associated with lower rates of earlier recurrence of Crohn's disease after resection.Human pathology · 2024Article
- How Reliable Is Endoscopic Scoring of Postoperative Recurrence in Crohn Disease?: A Systematic Review and Meta-Analysis.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Clinical Update on the Prevention and Management of Postoperative Crohn's Disease Recurrence.Current gastroenterology reports · 2024Review
- Perforating and nonperforating indications in repeated surgeries for Crohn's disease.World journal of clinical cases · 2022Article
- Risk factors for recurrence after bowel resection for Crohn's disease.World journal of gastrointestinal pharmacology and therapeutics · 2019Article
- Risk Stratification for Prevention of Recurrence of Postoperative Crohn's Disease.Gastroenterology & hepatology · 2017Article
- Predictors of postoperative recurrence in a cohort of Tunisian patients with Crohn's disease.Therapeutic advances in gastrointestinal endoscopyArticle
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Authors and funding
13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe utility of postoperative medical prophylaxis (POMP) and the treatment of mild endoscopic recurrence remain controversial.
methodsThis study is a retrospective review of patients undergoing a primary ileocolic resection for CD at a single academic center. Endoscopic recurrence (ER) was defined using the Rutgeerts score (RS), and clinical recurrence (CR) was defined as symptoms of CD with endoscopic or radiologic evidence of neo-terminal ileal disease.
resultsThere were 171 patients who met inclusion criteria. The cumulative probability of ER (RS ≥ i-1) at 1, 2, and 5 years was 29, 51, and 77 %, respectively. The only independent predictors of ER were the absence of POMP (HR 1.50; P = 0.03) and penetrating disease behavior (HR 1.50; P = 0.05). The cumulative probability of CR at 1, 2, and 5 years was 8, 13, and 27 %, respectively. There was a higher rate of clinical recurrence in patients with RS-2 compared to RS-1 on the initial postoperative endoscopy (HR 2.50; P = 0.02). In 11 patients not exposed to POMP with i-1 on initial endoscopy, only 2 patients (18 %) progressed endoscopically during the study period while 5 patients (45 %) regressed to i-0 on subsequent endoscopy without treatment.
conclusionsPostoperative medical prophylaxis decreased the likelihood of ER while certain phenotypes of CD appear to increase the risk of developing ER and CR. There may be a role for watchful waiting in patients with mild endoscopic recurrence on the initial postoperative endoscopy.
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