Evidence map›Paper›PMID 27778203›Full record

ArticleDigestive diseases and sciences2017

Tissue Transglutaminase Levels Are Not Sufficient to Diagnose Celiac Disease in North American Practices Without Intestinal Biopsies.

Yoram Elitsur, Terry Sigman, Runa Watkins, Anthony F Porto, Elaine L Leonard Puppa, Elsie J Foglio, Deborah L Preston

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In one paragraph

Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. An Overview of Celiac Disease in Childhood Type 1 Diabetes.International journal of endocrinology and metabolism · 2018
    Review
  8. Review
  9. Article
  10. The serological diagnosis of coeliac disease - a step forward.Gastroenterology and hepatology from bed to bench · 2018
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Yoram ElitsurDepartment of Pediatrics, Gastroenterology, Joan C Edwards Medical School, Marshall University, 1600 Medical Center Drive, Suite 3500, Huntington, WV, 25701, USA. elitsur@marshall.edu.ORCID 0000-0001-8831-6664
Terry SigmanDivision of Pediatric Gastroenterology, Montreal Children's Hospital, McGill University Health Center, McGill University, 1001 Boulevard Décarie, Montreal, QC, H4A 3J1, Canada.
Runa WatkinsDivision of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD, 21201-1559, USA.
Anthony F PortoDepartment of Pediatrics, Section of Gastroenterology and Hepatology, Yale University, 333 Cedar Street, PO Box 208064, New Haven, CT, 06520-8064, USA.
Elaine L Leonard PuppaDivision of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD, 21201-1559, USA.
Elsie J FoglioDepartment of Pediatrics, Section of Gastroenterology and Hepatology, Yale University, 333 Cedar Street, PO Box 208064, New Haven, CT, 06520-8064, USA.
Deborah L PrestonDepartment of Pediatrics, Gastroenterology, Joan C Edwards Medical School, Marshall University, 1600 Medical Center Drive, Suite 3500, Huntington, WV, 25701, USA.
Marshall University · USUniversity of Maryland, Baltimore · USYale University · USMontreal Children's Hospital · CA

Funding

YALE PEDIATRIC BASIC SCIENCE TRAINING PROGRAMT32HD068201 · NICHD · YALE UNIVERSITY · PI EGAN, MARIE E · 2011 to 2015
$1.3M
NICHD NIH HHS T32 HD068201
6 · The paper itself

Abstract

backgroundCeliac serology is crucial for the diagnosis of celiac disease in children. The American guideline for celiac disease in children suggested that positive serology should be followed by confirmatory intestinal histology. The relationship between high tissue transglutaminase titers and celiac disease in children has not been well investigated in children from North America.

aimsIn the present study, we investigated whether different tissue transglutaminase titers in symptomatic children could predict celiac disease without the confirmation of intestinal histology.

methodsData from biopsy confirmed celiac children were collected from four different clinics in North America. Clinical, serological, histological, and follow-up data were collected. The accuracy rates of various tissue transglutaminase titers to predict celiac disease in children were calculated.

resultsThe data from 240 children were calculated. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rate of tissue transglutaminase titers at ≥10× upper limit of normal were 75.4, 48.8, 87.7, 29.0, and 70.8 %, respectively. Similar data were noted in the other tissue transglutaminase titers (≥3× upper limit of normal, >100 U/ml, or >100 U/ml and >10× upper limit of normal).

conclusionsThe positive predictive value of tissue transglutaminase titers at ≥3× upper limit of normal or higher was too low to predict celiac disease in children. Our data suggested that in routine clinical practice, high titers of tissue transglutaminase are not sufficient to diagnose celiac disease in North American children without intestinal biopsies.

Indexed as

AdolescentAutoantibodiesBiopsyCeliac DiseaseChildChild, PreschoolDuodenumFemaleGTP-Binding ProteinsHumansImmunoglobulin AInfantIntestine, SmallMaleNorth AmericaPredictive Value of TestsAutoantibodiesGTP-Binding ProteinsImmunoglobulin AProtein Glutamine gamma Glutamyltransferase 2TransglutaminasesCeliacPediatricsSerologyTissue transglutaminase IgA titers

Identifiers

PMID27778203
OpenAlexW2537605021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.