Evidence map›Paper›PMID 27778157›Full record

ArticleJournal of neurology2017

Magnetic resonance imaging of the proximal upper extremity musculature in boys with Duchenne muscular dystrophy.

R J Willcocks, W T Triplett, S C Forbes, H Arora, C R Senesac, D J Lott, T R Nicholson, W D Rooney, G A Walter, K Vandenborne

Registry-linked trialAbstract read
In one paragraph

Article in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01484678 (Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01484678 recruitingnot on this mapstarted 2020, after this paper: background citation

Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy

TypeobservationalSponsorUniversity of FloridaRan2020 to 2026Enrolled550ConditionsDuchenne Muscular Dystrophy, Becker Muscular Dystrophy
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Review
  9. Ambulatory Duchenne muscular dystrophy children: cross-sectional correlation between function, quantitative muscle ultrasound and MRI.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2022
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

R J WillcocksDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA. rw254@phhp.ufl.edu.
W T TriplettDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
S C ForbesDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
H AroraDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
C R SenesacDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
D J LottDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
T R NicholsonAdvanced Magnetic Resonance Imaging and Spectroscopy Facility, University of Florida, Gainesville, FL, USA.
W D RooneyAdvanced Imaging Research Center, Oregon Health and Science University, Portland, OR, USA.
G A WalterDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA.
K VandenborneDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
University of Florida · USOregon Health & Science University · US

Funding

Magnetic Resonance Imaging and Biomarkers for Muscular DystropyR01AR056973 · NIAMS · UNIVERSITY OF FLORIDA · PI VANDENBORNE, KRISTA H · 2010 to 2024
$20.2M
The Relationship between Genomic Variants and MRI/MRS Markers in DMDR01AR065943 · NIAMS · UNIVERSITY OF FLORIDA · PI WALTER, GLENN · 2013 to 2015
$998k
A High-Performance Computing System for Advanced ImagingS10OD018224 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROONEY, WILLIAM D · 2014 to 2014
$222k
NIAMS NIH HHS R01 AR056973NIAMS NIH HHS R01 AR065943NIH HHS S10 OD018224
6 · The paper itself

Abstract

There is a pressing need for biomarkers and outcomes that can be used across disease stages in Duchenne muscular dystrophy (DMD), to facilitate the inclusion of a wider range of participants in clinical trials and to improve our understanding of the natural history of DMD. Quantitative magnetic resonance imaging (qMRI) and spectroscopy (MRS) biomarkers show considerable promise in both the legs and forearms of individuals with DMD, but have not yet been examined in functionally important proximal upper extremity muscles such as the biceps brachii and deltoid. The primary objective of this study was to examine the feasibility of implementing qMRI and MRS biomarkers in the proximal upper extremity musculature, and the secondary objective was to examine the relationship between MR measures of arm muscle pathology and upper extremity functional endpoints. Biomarkers included MRS and MRI measures of fat fraction and transverse relaxation time (T

Indexed as

AdolescentBiomarkersChildFeasibility StudiesHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMuscle, SkeletalMuscular Dystrophy, DuchenneUpper ExtremityBiomarkersBiomarkerMagnetic resonance spectroscopyNon-ambulatoryTransverse relaxation time

Identifiers

PMID27778157
PMCPMC5226881
OpenAlexW2532593119

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.