Evidence map›Paper›PMID 27778155›Full record

ReviewCurrent reviews in musculoskeletal medicine2016

Current management of aneurysmal bone cysts.

Howard Y Park, Sara K Yang, William L Sheppard, Vishal Hegde, Stephen D Zoller, Scott D Nelson, Noah Federman, Nicholas M Bernthal

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current reviews in musculoskeletal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 1 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 1 synthesis or guideline pooled it, 225 citations in OpenAlex.

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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Howard Y ParkDepartment of Orthopaedic Surgery, University of California, Los Angeles, 1250 16th St, Suite 2100, Santa Monica, CA, 90404, USA.
Sara K YangDepartment of Pediatrics, Hematology-Oncology, University of California, Los Angeles, Los Angeles, USA.
William L SheppardDepartment of Orthopaedic Surgery, University of California, Los Angeles, 1250 16th St, Suite 2100, Santa Monica, CA, 90404, USA.
Vishal HegdeDepartment of Orthopaedic Surgery, University of California, Los Angeles, 1250 16th St, Suite 2100, Santa Monica, CA, 90404, USA.
Stephen D ZollerDepartment of Orthopaedic Surgery, University of California, Los Angeles, 1250 16th St, Suite 2100, Santa Monica, CA, 90404, USA.
Scott D NelsonDepartment of Pathology & Laboratory Medicine, University of California, Los Angeles, Los Angeles, USA.
Noah FedermanDepartment of Pediatrics, Hematology-Oncology, University of California, Los Angeles, Los Angeles, USA.
Nicholas M BernthalDepartment of Orthopaedic Surgery, University of California, Los Angeles, 1250 16th St, Suite 2100, Santa Monica, CA, 90404, USA. nbernthal@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Regenerative Musculoskeletal Medicine Training ProgramT32AR059033 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI John S Adams, Nicholas M. Bernthal · 2011 to 2026
$4.8M
Modifying and Delivering Antimicrobials to Prevent Orthopaedic Implant InfectionsK08AR069112 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERNTHAL, NICHOLAS M. · 2016 to 2019
$704k
NIAMS NIH HHS K08 AR069112NIAMS NIH HHS T32 AR059033
6 · The paper itself

Abstract

Aneurysmal bone cysts (ABCs) are benign bone lesions arising predominantly in the pediatric population that can cause local pain, swelling, and pathologic fracture. Primary lesions, which constitute roughly two thirds of all ABCs, are thought to be neoplastic in nature, with one third of ABCs arising secondary to other tumors. Diagnosis is made with various imaging modalities, which exhibit characteristic features such as "fluid-fluid levels," although biopsy is critical, as telangiectatic osteosarcoma cannot be excluded based on imaging alone. Currently, the standard of care and most widely employed treatment is intralesional curettage. However, tumor recurrence with curettage alone is common and has driven some to propose a multitude of adjuvants with varying efficacy and risk profiles. Historically, therapies such as en bloc resection or radiation therapy were utilized as an alternative to decrease the recurrence rate, but these therapies imposed high morbidity. As a result, modern techniques now seek to simultaneously reduce morbidity and recurrence, the pursuit of which has produced preliminary study into minimally invasive percutaneous treatments and medical management.

Indexed as

Aneurysmal bone cystBenign bone tumorPediatric tumor

Identifiers

PMID27778155
PMCPMC5127951
OpenAlexW2536820219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.