ArticleJournal of neural transmission (Vienna, Austria : 1996)2017
Brain structural profile of multiple system atrophy patients with cognitive impairment.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- A study on the characteristics of cognitive function in patients with multiple system atrophy in China.Scientific reports · 2021Trial
- Cognitive and behavioral disturbances in PSP and MSA: clinical features and imaging correlates.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Functional MRI in Multiple System Atrophy: A Promising Biomarker for Clinical Applications.Neuropsychiatric disease and treatment · 2026Review
- MRI-derived atrophy in multiple system atrophy aligns with mitochondrial and glial gene expression patterns.NPJ Parkinson's disease · 2025Article
- Locus coeruleus neuromelanin, cognitive dysfunction, and brain metabolism in multiple system atrophy.Journal of neurology · 2025Article
- The Spectrum of Cognitive Impairment in Atypical Parkinsonism Syndromes: A Comprehensive Review of Current Understanding and Research.Diseases (Basel, Switzerland) · 2025Review
- Characteristics of cerebral glucose metabolism in patients with cognitive impairment in multiple system atrophy.Frontiers in aging neuroscience · 2025Article
- Magnetic Resonance T1w/T2w Ratio in the Putamen and Cerebellum as a Marker of Cognitive Impairment in MSA: a Longitudinal Study.Cerebellum (London, England) · 2023Article
- Mild cognitive impairment in multiple system atrophy: a brain network disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Alterations of voxel-wise spontaneous activity and corresponding brain functional networks in multiple system atrophy patients with mild cognitive impairment.Human brain mapping · 2023Article
- Large-scale activation likelihood estimation meta-analysis of parkinsonian disorders.Brain communications · 2023Article
- The Frontal and Cerebellar Metabolism Related to Cognitive Dysfunction in Multiple System Atrophy.Frontiers in aging neuroscience · 2022Article
- Pathogenesis and research progress in leukoaraiosis.Frontiers in human neuroscience · 2022Review
- Cognitive and Autonomic Dysfunction in Multiple System Atrophy Type P and C: A Comparative Study.Frontiers in neurology · 2022Article
- Cerebral Metabolism Related to Cognitive Impairments in Multiple System Atrophy.Frontiers in neurology · 2021Article
- Morphological Changes in Cortical and Subcortical Structures in Multiple System Atrophy Patients With Mild Cognitive Impairment.Frontiers in human neuroscience · 2021Article
- Vascular Risk Factors and Cognition in Multiple System Atrophy.Frontiers in neuroscience · 2021Article
- Early autonomic and cognitive dysfunction in PD, DLB and MSA: blurring the boundaries between α-synucleinopathies.Journal of neurology · 2020Article
- Neuropathological findings in multiple system atrophy with cognitive impairment.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Cognition in multiple system atrophy: a single-center cohort study.Annals of clinical and translational neurology · 2020Article
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Authors and funding
15 authors at 7 institutions in 3 countries.
Funding
Abstract
Current consensus diagnostic criteria for multiple system atrophy (MSA) consider dementia a non-supporting feature, although cognitive impairment and even frank dementia are reported in clinical practice. Mini-Mental State Examination (MMSE) is a commonly used global cognitive scale, and in a previous study, we established an MSA-specific screening cut-off score <27 to identify cognitive impairment. Finally, MSA neuroimaging findings suggest the presence of structural alterations in patients with cognitive deficits, although the extent of the anatomical changes is unclear. The aim of our multicenter study is to better characterize anatomical changes associated with cognitive impairment in MSA and to further investigate cortical and subcortical structural differences versus healthy controls (HC). We examined retrospectively 72 probable MSA patients [50 with normal cognition (MSA-NC) and 22 cognitively impaired (MSA-CI) based on MMSE <27] and compared them to 36 HC using gray- and white-matter voxel-based morphometry and fully automated subcortical segmentation. Compared to HC, MSA patients showed widespread cortical (bilateral frontal, occipito-temporal, and parietal areas), subcortical, and white-matter alterations. However, MSA-CI showed only focal volume reduction in the left dorsolateral prefrontal cortex compared with MSA-NC. These results suggest only a marginal contribution of cortical pathology to cognitive deficits. We believe that cognitive dysfunction is driven by focal fronto-striatal degeneration in line with the concept of "subcortical cognitive impairment".
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