Observational studyIntensive care medicine2017
Clusters of ineffective efforts during mechanical ventilation: impact on outcome.
Observational study in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 173 citations in OpenAlex.
- Acquisition of respiratory surface EMG: a systematic literature review of electrode configurations and methodological reporting.Critical care (London, England) · 2025Pooled it
- The effects of real-time waveform analysis software on patient ventilator synchronization during pressure support ventilation: a randomized crossover physiological study.BMC pulmonary medicine · 2024Trial
- Impact on the ability of healthcare professionals to correctly identify patient-ventilator asynchronies of the simultaneous visualization of estimated muscle pressure curves on the ventilator display: a randomized study (PCritical care (London, England) · 2023Trial
- How I Teach Mechanical Ventilator Waveform Analysis: A Focus on Normal Ventilator Waveforms.ATS scholar · 2026Article
- Challenges and strategies for the identification and correction of patient-ventilator asynchronies in daily practice: a scoping review.Acute and critical care · 2026Article
- Ventilator waveform interpretation skills of attending intensivists relative to critical care fellows (VISA) study.ATS scholar · 2026Article
- Consensus on identifying and ranking ventilator asynchronies in invasively ventilated ICU patients: a modified Delphi study (SYNAPsE).Intensive care medicine · 2026Article
- Patient-ventilator asynchrony: physiological causes and clinical aspects.Intensive care medicine · 2026Article
- PVADet: fast patient-ventilator asynchrony detection on waveforms.Journal of clinical monitoring and computing · 2026Article
- Ventilatory asynchronies induced by routine clinical practices in the intensive care unit: A systematic observation combined with a scoping review.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2026Article
- Asynchrony index modified: An improved tool for estimating the quality of patient-ventilator interaction.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2026Article
- Methodological development of the remote ventilate view platform for real-time monitoring of patient-ventilator asynchrony and respiratory parameters in severe pneumonia patients.Journal of intensive medicine · 2025Article
- Ability to identify patient-ventilator asynchronies in intensive care unit professionals: A multicenter cross-sectional analytical study.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
- Induction of subject-ventilator asynchrony by variation of respiratory parameters in a lung injury model in pigs.Respiratory research · 2024Article
- Article
- Reverse triggering ? a novel or previously missed phenomenon?Annals of intensive care · 2024Article
- Respiratory drive: a journey from health to disease.Journal of intensive care · 2024Review
- Pathophysiology of acute lung injury in patients with acute brain injury: the triple-hit hypothesis.Critical care (London, England) · 2024Review
- Specific Training Improves the Detection and Management of Patient-Ventilator Asynchrony.Respiratory care · 2024Article
- Understanding the mechanisms of ventilator-induced lung injury using animal models.Intensive care medicine experimental · 2023Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to investigate the role of ineffective efforts (IEs), specifically clusters of IEs, during mechanical ventilation on the outcome of critically ill patients.
methodsIn a prospective observational study, 24-h recordings were obtained in 110 patients on the 1st day of assisted ventilation (pressure support or proportional assist), using a prototype monitor validated to identify IEs. Patients remaining on assisted ventilation were studied again on the 3rd day (n = 37) and on the 6th day (n = 13). To describe the clusters of IEs, the concept of an IEs event was developed, defined as a 3-min period of time containing more than 30 IEs. Along with all patient data, to minimize selection bias by time of recording, analysis was performed only on 1st day data of patients with ≥16 h of recording (1st day group).
resultsThe analysis included 2931 h of assisted ventilation and 4,456,537 breaths. Neither the IEs index (IEs as a percentage of total breaths) in general nor a value above 10 % was correlated with patient outcome. Overall, IEs events were identified in 38 % of patients. In multivariate analysis, the presence of events in the 1st day group (n = 79) was associated with the risk of being on mechanical ventilation ≥8 days after first recording [odds ratio 6.4, 95 % confidence interval (1.1-38.30)] and hospital mortality [20 (2.3-175)]. Analysis of the data for all patients revealed similarly increased risks for prolonged ventilation [3.4 (1.1-10.7)] and mortality [4.9 (1.3-18)].
conclusionsClusters of IEs are often present in mechanically ventilated critically ill patients and are associated with prolonged mechanical ventilation and increased mortality. Studies to find ways of improving patient-ventilator interaction are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.