Evidence map›Paper›PMID 27777978›Full record

ArticleJCI insight2016

Acquired resistance to innate immune clearance promotes

Danielle Ahn, Hernán Peñaloza, Zheng Wang, Matthew Wickersham, Dane Parker, Purvi Patel, Antonius Koller, Emily I Chen, Susan M Bueno, Anne-Catrin Uhlemann and 1 more

Open access · goldAbstract read
In one paragraph

Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
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  14. Distinctive features and prognostic utility of neutrophil in severe patients withFrontiers in cellular and infection microbiology · 2024
    Article
  15. Interactions and Implications ofInfection and drug resistance · 2024
    Review
  16. Article
  17. Immunometabolic control byImmunometabolism (Cobham, Surrey) · 2023
    Review
  18. Phagocytosis is a primary determinant of pulmonary clearance of clinicalFrontiers in cellular and infection microbiology · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Danielle AhnDepartment of Pediatrics, Columbia University Medical Center, New York, New York, USA.
Hernán PeñalozaMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Zheng WangDepartment of Medicine, Columbia University Medical Center, New York, New York, USA.
Matthew WickershamDepartment of Pediatrics, Columbia University Medical Center, New York, New York, USA.
Dane ParkerDepartment of Pediatrics, Columbia University Medical Center, New York, New York, USA.
Purvi PatelProteomics Shared Resource at the Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA.
Antonius KollerProteomics Shared Resource at the Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA.
Emily I ChenProteomics Shared Resource at the Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA.
Susan M BuenoMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Anne-Catrin UhlemannDepartment of Medicine, Columbia University Medical Center, New York, New York, USA.
Alice PrinceDepartment of Pediatrics, Columbia University Medical Center, New York, New York, USA.
Columbia University Irving Medical Center · USMillennium Institute on Immunology and Immunotherapy · CL

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3M
Pediatric Critical Care Scientist Development ProgramK12HD047349 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI HEATHER T. KEENAN, Kevin M Watt · 2004 to 2026
$17.0M
Innate Immune Clearance of Host-Adapted Pulmonary PathogensR35HL135800 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PRINCE, ALICE S · 2017 to 2023
$5.9M
Calcium Dependent Signaling Pathways in Epithelial CellsR01HL073989 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PRINCE, ALICE S · 2005 to 2016
$4.3M
Carbapenem-resistant bacterial colonization and infection after liver transplantR01AI116939 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI UHLEMANN, ANNE-CATRIN · 2015 to 2019
$2.4M
Becton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413k
NCI NIH HHS P30 CA013696NCRR NIH HHS S10 RR027050NHLBI NIH HHS R01 HL073989NHLBI NIH HHS R35 HL135800NIAID NIH HHS R01 AI116939NICHD NIH HHS K12 HD047349
6 · The paper itself

Abstract

Adaptive changes in the genome of a locally predominant clinical isolate of the multidrug-resistant

Indexed as

Drug Resistance, Multiple, BacterialImmunity, InnateAmino Acid Transport SystemsAnimalsAntiportersBacterial ProteinsCytokinesHumansKlebsiella InfectionsKlebsiella pneumoniaeMaleMiceMice, Inbred C57BLMonocytesNeutrophilsPhagocytosisAmino Acid Transport SystemsAntiportersArcD protein, BacteriaBacterial ProteinsCytokines

Identifiers

PMID27777978
PMCPMC5070956
OpenAlexW2536025871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.