ArticleJCI insight2016
PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.
Open access · goldAbstract read
In one paragraph
Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes.Journal of physiological anthropology · 2025Pooled it
- Osteopetrosis: Pathogenesis, Clinical Management, and Emerging Therapies.Current osteoporosis reports · 2026Review
- Osteocytes regulate osteoprotegerin expression via the p38-MAPK-CREB pathway in rheumatoid arthritis.JBMR plus · 2026Article
- Can transient neonatal osteosclerosis be differentiated from malignant infantile osteopetrosis?Bone reports · 2025Article
- The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions.eLife · 2025Article
- A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.Molecular psychiatry · 2025Article
- Architecture mechanics mediated osteogenic progression in bone regeneration of artificial scaffolds.Science advances · 2025Article
- HOPS-dependent vesicle tethering lock inhibits endolysosomal fusions and autophagosome secretion upon the loss of Syntaxin17.Science advances · 2025Article
- Lysosomes as Dynamic Regulators of Metabolic Signaling and Organ Physiology in Aging: From Mechanism to Therapy.Aging and disease · 2025Review
- Article
- Lysosome-Iron-Mitochondria Axis in Osteoclasts: Iron as a Central Player.Research (Washington, D.C.) · 2025Review
- Tcirg1 deficiency delays osteoarthritis progression by impairing lysosome acidification and peripheral accumulation in osteoclasts.Frontiers in cell and developmental biology · 2025Article
- The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis.Autophagy · 2024Article
- Article
- RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts.Bone research · 2024Article
- Article
- PolyAMiner-Bulk is a deep learning-based algorithm that decodes alternative polyadenylation dynamics from bulk RNA-seq data.Cell reports methods · 2024Article
- Yunnan Baiyao Might Mitigate Periodontitis Bone Destruction by Inhibiting Autophagy and Promoting Osteoblast Differentiation in vivo, ex vivo and in vitro.Journal of inflammation research · 2024Article
- Lysosomal biogenesis and function in osteoclasts: a comprehensive review.Frontiers in cell and developmental biology · 2024Review
- Osteogenic mechanism of chlorogenic acid and its application in clinical practice.Frontiers in pharmacology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 3 countries.
Toshifumi FujiwaraCenter for Osteoporosis and Metabolic Bone Diseases, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Shiqiao YeCenter for Osteoporosis and Metabolic Bone Diseases, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Thiago Castro-GomesDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Caylin G WinchellDepartment of Microbiology and Immunology.
Norma W AndrewsDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Daniel E VothDepartment of Microbiology and Immunology.
Kottayil I VarugheseDepartment of Physiology and Biophysics, and.
Samuel G MackintoshDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Yunfeng FengDepartment of Pathology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Nathan PavlosCenter for Orthopedic Research, Dentistry and Health Sciences, The University of Western Australia, Nedlands, Western Australia, Australia.
Takashi NakamuraDepartment of Biochemistry & Integrative Medical Biology, School of Medicine, Keio University, Tokyo, Japan.
Stavros C ManolagasCenter for Osteoporosis and Metabolic Bone Diseases, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Haibo ZhaoCenter for Osteoporosis and Metabolic Bone Diseases, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Institute of Molecular Biology and Biophysics · RUUniversity of Maryland, College Park · USDartmouth College · USKeio University · JPUniversity of Arkansas for Medical Sciences · US
Funding
Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9MTRANSGENIC MOUSE COREP01AG013918 · NIA · UNIV OF ARKANSAS FOR MED SCIS · PI O'BRIEN, CHARLES A · 1996 to 2016
$25.7MStudy of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5MMechanisms of Cytoskeletal and Lysosomal Protein Regulation in OsteoclastsR01AR062012 · NIAMS · UNIV OF ARKANSAS FOR MED SCIS · PI ZHAO, HAIBO · 2011 to 2015
$1.6MSuper-Resolution Light Microscope at University of Arkansas for Medical SciencesS10OD018065 · OD · UNIV OF ARKANSAS FOR MED SCIS · PI STORRIE, BRIAN · 2015 to 2015
$600kStructural and functional analyses of Rab7 binding to Plekhm1R21AR068509 · NIAMS · UNIV OF ARKANSAS FOR MED SCIS · PI VARUGHESE, KOTTAYIL I, ZHAO, HAIBO · 2016 to 2017
$361kBLRD VA I01 BX001405NIAMS NIH HHS R01 AR062012NIAMS NIH HHS R21 AR068509NIA NIH HHS P01 AG013918NIGMS NIH HHS P20 GM103429NIGMS NIH HHS P20 GM103625NIH HHS S10 OD018065
Abstract
Mutations of the
Indexed as
Bone ResorptionAdaptor Proteins, Signal TransducingAnimalsAutophagy-Related ProteinsCell DifferentiationCells, CulturedEndosomesGene DeletionHomeostasisLysosomesMiceMice, Inbred C57BLOsteoclastsrab7 GTP-Binding Proteinsrab GTP-Binding ProteinsVesicular Transport ProteinsAdaptor Proteins, Signal TransducingAutophagy-Related ProteinsPlekhm1 protein, mouserab7 GTP-Binding Proteinsrab7 GTP-binding proteins, humanrab7 GTP-binding proteins, mouserab7 GTP-binding proteins, ratrab GTP-Binding ProteinsVesicular Transport Proteins
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.