ReviewJournal of clinical and translational hepatology2016
Hypoxic Hepatitis: A Review and Clinical Update.
Review in Journal of clinical and translational hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 143 citations in OpenAlex.
- Heart-Liver Interactions: Pathophysiology and Diagnosis of Hypoxic Hepatitis, Congestive Hepatopathy, and Cirrhotic Cardiomyopathy.Diagnostics (Basel, Switzerland) · 2026Review
- Development and evaluation of machine learning-based prediction-modelling for initial vancomycin serum concentrations in septic ICU patients using clinical health record data.Intensive care medicine experimental · 2026Article
- The Liver as a Biomarker Organ in Heart Failure: Molecular Mechanisms, Hepatic Scores and Systemic Risk Stratification.International journal of molecular sciences · 2026Review
- Adult Hepatic Infarction for Internists: A Practical Diagnostic and Management Pathway to Avoid Misdiagnosis, Unnecessary Drainage, and Delayed Vascular Recognition.Healthcare (Basel, Switzerland) · 2026Review
- Association of alkaline phosphatase to platelet ratio index with ICU mortality in patients with cardiac arrest.BMC cardiovascular disorders · 2026Article
- Liver enzyme trajectory and risk factors for acute liver failure in patients with exertional heatstroke: a retrospective analysis.Internal and emergency medicine · 2026Article
- Delayed Ischemic Hepatocellular Injury Following Cemented Total Hip Arthroplasty: A Case Report Within the Spectrum of Bone Cement Implantation Syndrome.Life (Basel, Switzerland) · 2026Article
- Protective effect of ischemic preconditioning against hepatic ischemia-reperfusion injury and associated remote organ damage.World journal of gastrointestinal surgery · 2026Review
- Article
- Prognostic Value of the Total Bilirubin-to-Albumin Ratio in Critically Ill Patients with Gastrointestinal Bleeding: A Multicentre Cohort Study.Emergency medicine international · 2026Article
- Association of sST2 with liver function in patients with acute heart failure related hospitalization.Frontiers in cardiovascular medicine · 2026Article
- Development and internal validation of a prediction model for hypoxic hepatitis after coronary artery bypass grafting with cardiopulmonary bypass.Frontiers in medicine · 2026Article
- Hypertransaminasemia in non-cirrhotic critically-ill patients.World journal of hepatology · 2025Review
- Multiple Organ Failure as a Strong Predictor of Mortality in Patients with Hypoxic Hepatitis.Journal of clinical medicine · 2025Article
- Fibrosing Mediastinitis in a 5-Year-Old Labrador Retriever.Veterinary medicine and science · 2025Article
- Development and validation of a predictive model for postoperative hepatic dysfunction in Stanford type A aortic dissection.Scientific reports · 2025Article
- Two types of regenerative cell populations appear in acute liver injury.Stem cell reports · 2025Article
- Pre-infection liver function is associated with all-cause mortality among hemodialysis patients with SARS-CoV-2 Omicron variant infection.Renal failure · 2024Article
- Recent advances in COVID-19-induced liver injury: causes, diagnosis, and management.Inflammopharmacology · 2024Review
- Acute High-Output Heart Failure with Pulmonary Hypertension and Severe Liver Injury Caused by Amlodipine Poisoning: A Case Report.Cardiovascular toxicology · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxic hepatitis (HH), also known as ischemic hepatitis or shock liver, is characterized by a massive, rapid rise in serum aminotransferases resulting from reduced oxygen delivery to the liver. The most common predisposing condition is cardiac failure, followed by circulatory failure as occurs in septic shock and respiratory failure. HH does, however, occur in the absence of a documented hypotensive event or shock state in 50% of patients. In intensive care units, the incidence of HH is near 2.5%, but has been reported as high as 10% in some studies. The pathophysiology is multifactorial, but often involves hepatic congestion from right heart failure along with reduced hepatic blood flow, total body hypoxemia, reduced oxygen uptake by hepatocytes or reperfusion injury following ischemia. The diagnosis is primarily clinical, and typically does not require liver biopsy. The definitive treatment of HH involves correction of the underlying disease state, but successful management includes monitoring for the potential complications such as hypoglycemia, hyperglycemia, hyperammonemia and hepatopulmonary syndrome. Prognosis of HH remains poor, especially for cases in which there was a delay in diagnosis. The in-hospital mortality rate is >50%, and the most frequent cause of death is the predisposing condition and not the liver injury itself.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.