ArticleIEEE journal of translational engineering in health and medicine2016
Non-Invasive Neuromodulation Using Time-Varying Caloric Vestibular Stimulation.
Article in IEEE journal of translational engineering in health and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Pilot Study to Evaluate a Non-Invasive, Neurostimulation Device for Treatment of Migraine Headache
Pilot Investigation of at Home Caloric Vestibular Neuromodulation for Use in Substance Use Disorders
Who cites it
17 citing papers in PubMed.
- Unilateral Spatial Neglect After Stroke: A Pragmatic Approach to Assessment and Rehabilitation.Journal of clinical medicine · 2026Review
- Vestibular Neurostimulation for Parkinson's Disease: A Novel Device-Aided Non-Invasive Therapeutic Option.Journal of personalized medicine · 2024Review
- Cognition in vestibular disorders: state of the field, challenges, and priorities for the future.Frontiers in neurology · 2024Review
- Vestibular Sensory Conflict During Postural Control, Freezing of Gait, and Falls in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Cholinergic brain network deficits associated with vestibular sensory conflict deficits in Parkinson's disease: correlation with postural and gait deficits.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Mild Therapeutic Hypothermia and Putative Mechanisms of Hair Cell Survival in the Cochlea.Antioxidants & redox signaling · 2022Article
- Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches.The Lancet. Neurology · 2022Review
- Time-varying caloric vestibular stimulation for the treatment of neurodegenerative disease.Frontiers in aging neuroscience · 2022Article
- Non-Pharmacological Approaches to Headaches: Non-Invasive Neuromodulation, Nutraceuticals, and Behavioral Approaches.International journal of environmental research and public health · 2021Review
- The Acute Effects of Time-Varying Caloric Vestibular Stimulation as Assessed With fMRI.Frontiers in systems neuroscience · 2021Article
- Noninvasive Neuromodulation in Migraine.Current pain and headache reports · 2020Review
- Peripheral Neuromodulation for the Management of Headache.Anesthesiology and pain medicine · 2020Review
- Sensory Neuromodulation.Frontiers in systems neuroscience · 2020Article
- Caloric vestibular stimulation for the management of motor and non-motor symptoms in parkinson's disease: Intention-to-treat data.Data in brief · 2019Article
- Article
- A new era in headache treatment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Review
- New treatments for headache.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caloric vestibular stimulation (CVS) to elicit the vestibulo-ocular reflex has long been used in clinical settings to aid in the diagnosis of balance disorders and to confirm the absence of brainstem function. While a number of studies have hinted at the potential therapeutic applications of CVS, the limitations of existing devices have frustrated that potential. Current CVS irrigators use water or air during short-duration applications; however, this approach is not tenable for longer duration therapeutic protocols or home use. Here, we describe a solid-state CVS device we developed in order to address these limitations. This device delivers tightly controlled time-varying thermal waveforms, which can be programmed through an external control unit. It contains several safety features, which limit patients to the prescribed waveform and prevent the potential for temperature extremes. In this paper, we provide evidence that CVS treatment with time-varying, but not constant temperature waveforms, elicits changes in cerebral blood flow physiology consistent with the neuromodulation of brainstem centers, and we present results from a small pilot study, which demonstrate that the CVS can safely and feasibly be used longitudinally in the home setting to treat episodic migraine. Together, these results indicate that this solid-state CVS device may be a viable tool for non-invasive neuromodulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.