Evidence map›Paper›PMID 27777642›Full record

ArticleThe World Allergy Organization journal2016

Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement.

Marek L Kowalski, Ignacio Ansotegui, Werner Aberer, Mona Al-Ahmad, Mubeccel Akdis, Barbara K Ballmer-Weber, Kirsten Beyer, Miguel Blanca, Simon Brown, Chaweewan Bunnag and 39 more

Erratum issuedAbstract read
In one paragraph

Article in The World Allergy Organization journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Nasal nitric oxide measurement in allergic rhinitis and non-allergic rhinitis: a meta-analysis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024
    Pooled it
  2. Intralymphatic immunotherapy with birch and grass pollen extracts. A randomized double-blind placebo-controlled clinical trial.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023
    Trial
  3. Intralymphatic immunotherapy with one or two allergens renders similar clinical response in patients with allergic rhinitis due to birch and grass pollen.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Trial
  4. Outpatient oxaliplatin desensitizations: A process improvement evaluation.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019
    Trial
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  14. Diagnostics of allergic rhinitis under dupilumab therapy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Oral and nasal provocation test in chicken egg allergy-case report.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

49 authors.

Marek L KowalskiDepartment of Immunology, Rheumatology & Allergy, Medical University of Lodz, 251 Pomorska Str, 92-213 Lodz, Poland.
Ignacio AnsoteguiDepartment of Allergy and Immunology, Hospital Quiron Bizkaia, Bilbao, Spain.
Werner AbererDepartment of Dermatology, Medical University of Graz, Graz, Austria.
Mona Al-AhmadMicrobiology Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
Mubeccel AkdisSwiss institute of Allergy & Asthma research, Davos, Switzerland.
Barbara K Ballmer-WeberAllergy Unit, Dermatology Clinic, University Hospital Zürich, University Zürich, Zürich, Switzerland.
Kirsten BeyerKirsten Beyer, Charité Universitätsmedizin Berlin, Klinik für Pädiatrie m.S. Pneumologie und Immunologie, Berlin, Germany.
Miguel BlancaHospital Reg. Univ. Carlos Haya, Allergy Serv, Malaga, Spain.
Simon BrownRoyal Perth Hospital, Department of Emergency Medicine, Perth, WA Australia.
Chaweewan BunnagDepartment of Otolaryngology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Arnaldo Capriles HulettAllergology Unit, Hospital San Juan de Dios, Caracas, Venezuela.
Mariana CastellsBrigham & Women's Hospital, Harvard Medical School, Boston, MA USA.
Hiok Hee ChngDepartment of Rheumatology, Allergy & Immunology, Tan Tock Seng Hospital, Singapore, Singapore.
Frederic De BlayHôpitaux Universitaires de Strasbourg, Chest Diseases Department, Strasbourg, France.
Motohiro EbisawaDepartment of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Sagamihara, Kanagawa Japan.
Stanley FinemanEmory University School of Medicine, Atlanta Allergy & Asthma, Atlanta, Georgia.
David B K GoldenJohns Hopkins University, Baltimore, MD USA.
Tari HaahtelaHelsinki University Central Hospital, Helsinki, Finland.
Michael KalinerInstitute for Asthma & Allergy, Bethesda, MD USA.
Connie KatelarisWestmead Medical Centre, Westmead, NSW Australia.
Bee Wah LeeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Joanna MakowskaCSK, Department of Allergy & Clinical Immunology, Lodz, Poland.
Ulrich MullerSpitalnetz, Bern, Switzerland.
Joaquim MullolRhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, and CIBERES, Barcelona, Spain.
John OppenheimerUMDNJ - Rutgers Medical School, c/o Pulmonary and Allergy Associates, Summit, New Jersey, USA.
Hae-Sim ParkDepartment of Internal Medicine, Ajou University School of Medicine, Suwon, South Korea.
James ParkersonUniversity of South Florida, Tampa, FL USA.
Giovanni PassalacquaAllergy and Respiratory Diseases, IRCCS San Martino Hospital IST, University of Genoa, Genoa, Italy.
Ruby PawankarDepartment of Pediatrics, Nippon Medical School, Tokyo, Japan.
Harald RenzUniversitatsklinikum GI & MR GmbH, Institut fur Laboratoriumsmedizin & Path, Standort Marburg, Marburg, Germany.
Franziska RueffKlinikum der Ludwig-Maximilians-Universitat, Klinik & Poliklinik fur Dermatologie & Allergologie, Munchen, Germany.
Mario Sanchez-BorgesAllergy and Clinical Immunology Department, Centro Medico-Docente La Trinidadad, Caracas, Venezuela.
Joaquin SastreAllergy Department, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, CIBER de Enfermedades Respiratorias (CIBERES), Institute Carlos III, Madrid, Spain.
Glenis ScaddingRNTNE Hospital, London, UK.
Scott SichererDivision of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY USA.
Pongsakorn TantilipikornDepartment of Otolaryngology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
James TracyUniversity of Nebraska, Omaha, NE USA.
Vera van KempenInstitute for Prevention and Occupational Medicine, German Social Accident Insurance, Ruhr-University Bochum (IPA), Bochum, Germany.
Barbara BohleDivision of Experimental Allergology, Department of Pathophysiology, Allergy Research Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria.
G Walter CanonicaAllergy & Respiratory Disease Clinic, DIMI - Department Int Med, University of Genoa, IRCCS AOU, San Martino - IST, Genoa, Italy.
Luis CaraballoImmunology Department, Universidad De Cartagena, Cartagena, Colombia.
Maximiliano GomezHospital San Bernardo, Salta, Argentina.
Komei ItoDepartment of Allergy, Aichi Children's Health and Medical Center, Aichi, Japan.
Erika Jensen-JarolimMesserli Research Institute, Medical University Vienna, University Vienna, Vienna, Austria.
Mark LarcheDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.
Giovanni MelioliIstituto Giannina Gaslini, Genoa, Italy.
Lars K PoulsenGentofte University Hospital, Lab for Allergology, Allergy Clinic, Hellerup, Denmark.
Rudolf ValentaDepartment of Pathophysiology, AKH, Wien, Austria.
Torsten ZuberbierCampus Charite Mitte, Klinik fur Dermatologie & Allergologie, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the major concerns in the practice of allergy is related to the safety of procedures for the diagnosis and treatment of allergic disease. Management (diagnosis and treatment) of hypersensitivity disorders involves often intentional exposure to potentially allergenic substances (during skin testing), deliberate induction in the office of allergic symptoms to offending compounds (provocation tests) or intentional application of potentially dangerous substances (allergy vaccine) to sensitized patients. These situations may be associated with a significant risk of unwanted, excessive or even dangerous reactions, which in many instances cannot be completely avoided. However, adverse reactions can be minimized or even avoided if a physician is fully aware of potential risk and is prepared to appropriately handle the situation. Information on the risk of diagnostic and therapeutic procedures in allergic diseases has been accumulated in the medical literature for decades; however, except for allergen specific immunotherapy, it has never been presented in a systematic fashion. Up to now no single document addressed the risk of the most commonly used medical procedures in the allergy office nor attempted to present general requirements necessary to assure the safety of these procedures. Following review of available literature a group of allergy experts within the World Allergy Organization (WAO), representing various continents and areas of allergy expertise, presents this report on risk associated with diagnostic and therapeutic procedures in allergology and proposes a consensus on safety requirements for performing procedures in allergy offices. Optimal safety measures including appropriate location, type and required time of supervision, availability of safety equipment, access to specialized emergency services, etc. for various procedures have been recommended. This document should be useful for allergists with already established practices and experience as well as to other specialists taking care of patients with allergies.

Identifiers

PMID27777642
PMCPMC5062928

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.