Evidence map›Paper›PMID 27777629›Full record

ArticleEpigenetics & chromatin2016

An H4K16 histone acetyltransferase mediates decondensation of the X chromosome in

Alyssa C Lau, Kevin P Zhu, Elizabeth A Brouhard, Michael B Davis, Györgyi Csankovszki

Open access · goldAbstract read
In one paragraph

Article in Epigenetics & chromatin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Compensation of gene dosage on the mammalian X.Development (Cambridge, England) · 2024
    Review
  3. Article
  4. Article
  5. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alyssa C LauDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N. University Ave., Ann Arbor, MI 48109-1048 USA ; Genome Technologies, The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032 USA.
Kevin P ZhuDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N. University Ave., Ann Arbor, MI 48109-1048 USA.
Elizabeth A BrouhardDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N. University Ave., Ann Arbor, MI 48109-1048 USA.
Michael B DavisDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N. University Ave., Ann Arbor, MI 48109-1048 USA.
Györgyi CsankovszkiDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N. University Ave., Ann Arbor, MI 48109-1048 USA.
University of Michigan–Ann Arbor · US

Funding

The Dosage Compensation Machinery of C. ElegansR01GM079533 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CSANKOVSZKI, GYORGYI · 2007 to 2015
$2.5M
NIGMS NIH HHS R01 GM079533
6 · The paper itself

Abstract

backgroundIn

resultsTo gain more insight into X upregulation, we studied the effects of chromatin condensation and histone acetylation on gene expression levels in male

conclusionThese results indicate that H4K16ac and chromosome decondensation influence regulation of the male X chromosome; however, they do not fully account for the high levels of gene expression observed on the X chromosomes.

Indexed as

AcetylationAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsChromatinChromatin Assembly and DisassemblyChromatin ImmunoprecipitationDosage Compensation, GeneticGene ExpressionHistone AcetyltransferasesHistonesIn Situ Hybridization, FluorescenceMaleSequence Analysis, DNAX ChromosomeCaenorhabditis elegans ProteinsChromatinHistone AcetyltransferasesHistonesMYS-1 protein, C elegansCaenorhabditis elegansChromatinChromosome territoriesDosage compensationEpigeneticsGene expressionHistone acetylation

Identifiers

PMID27777629
PMCPMC5070013
OpenAlexW2538781484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.