Evidence map›Paper›PMID 27777588›Full record

ArticleStem cells international2016

A Transcriptomic Signature of Mouse Liver Progenitor Cells.

Adam M Passman, Jasmine Low, Roslyn London, Janina E E Tirnitz-Parker, Atsushi Miyajima, Minoru Tanaka, Helene Strick-Marchand, Gretchen J Darlington, Megan Finch-Edmondson, Scott Ochsner and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 5 countries.

Adam M PassmanSchool of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.ORCID 0000-0003-3212-6938
Jasmine LowSchool of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, WA 6009, Australia.
Roslyn LondonSchool of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia.ORCID 0000-0002-7032-2756
Janina E E Tirnitz-ParkerSchool of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia; School of Medicine and Pharmacology, The University of Western Australia, Fremantle, WA 6160, Australia.ORCID 0000-0002-3558-5892
Atsushi MiyajimaInstitute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-8654, Japan.
Minoru TanakaInstitute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-8654, Japan.
Helene Strick-MarchandUnité de Génétique de la Différenciation, Institut Pasteur, 75015 Paris, France.
Gretchen J DarlingtonHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Megan Finch-EdmondsonDepartment of Physiology, NUS Yong Loo Lin School of Medicine, Singapore 117411; Mechanobiology Institute (MBI), National University of Singapore, Singapore 117411.ORCID 0000-0002-9628-5842
Scott OchsnerDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Cornelia ZhuSchool of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.
James WhelanARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, WA 6009, Australia; Department of Animal, Plant and Soil Sciences, La Trobe University, Melbourne, VIC 3086, Australia.
Bernard A CallusSchool of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia; School of Health Sciences, The University of Notre Dame Australia, Fremantle, WA 6959, Australia.
George C T YeohSchool of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.ORCID 0000-0002-4740-4702
The University of Western Australia · AUBaylor College of Medicine · USThe University of Tokyo · JPInstitut Pasteur · FRNational University of Singapore · SG

Funding

Worldwide Cancer Research 09-0084
6 · The paper itself

Abstract

Liver progenitor cells (LPCs) can proliferate extensively, are able to differentiate into hepatocytes and cholangiocytes, and contribute to liver regeneration. The presence of LPCs, however, often accompanies liver disease and hepatocellular carcinoma (HCC), indicating that they may be a cancer stem cell. Understanding LPC biology and establishing a sensitive, rapid, and reliable method to detect their presence in the liver will assist diagnosis and facilitate monitoring of treatment outcomes in patients with liver pathologies. A transcriptomic meta-analysis of over 400 microarrays was undertaken to compare LPC lines against datasets of muscle and embryonic stem cell lines, embryonic and developed liver (DL), and HCC. Three gene clusters distinguishing LPCs from other liver cell types were identified. Pathways overrepresented in these clusters denote the proliferative nature of LPCs and their association with HCC. Our analysis also revealed 26 novel markers, LPC markers, including

Identifiers

PMID27777588
PMCPMC5061959
OpenAlexW2525201804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.