Evidence map›Paper›PMID 27777505›Full record

ArticleMolecular vision2016

Plasma endothelin-1 and single nucleotide polymorphisms of

Ewa Kosior-Jarecka, Dominika Wróbel-Dudzińska, Urszula Łukasik, Tin Aung, Chiea Chuen Khor, Janusz Kocki, Tomasz Żarnowski

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PubMed Full text at PMC
In one paragraph

Article in Molecular vision, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Astrocyte Immune Functions and Glaucoma.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Novel insights into non-HLA alloimmunity in kidney transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ewa Kosior-JareckaDepartment of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland.
Dominika Wróbel-DudzińskaDepartment of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland.
Urszula ŁukasikDepartment of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland.
Tin AungDepartment of Ophthalmology, National University Health System, National University of Singapore; Singapore Eye Research Institute, Singapore; Singapore National Eye Center, Singapore.
Chiea Chuen KhorGenome Institute of Singapore, Singapore; Singapore Eye Research Institute, Singapore, Singapore.
Janusz KockiDepartment of Clinical Genetics, Medical University, Lublin, Poland.
Tomasz ŻarnowskiDepartment of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland.
Medical University of Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to determine whether four single nucleotide polymorphisms (SNPs) of

methodsThe study included 160 patients with NTG, 124 patients with HTG, and 165 healthy controls. To analyze the frequency of polymorphic variants of the

resultsThere was a significant difference between the patients with NTG and HTG and the controls (p = 0.035, p = 0.008) regarding the genotype of the C1222T and C70G polymorphism. Plasma concentrations of ET did not differ between the NTG and HTG groups, and no significant correlation with intraocular pressure (IOP), best-corrected visual acuity (BCVA), and the cup to disc ratio (c/d ratio) was seen in patients with NTG. Plasma endothelin levels showed a noticeably positive correlation with age in the NTG group (R = 0.249, p = 0.042). Higher endothelin levels corresponded to more advanced visual field damage. No statistical difference was observed between variant genotypes of K198N and the ET-1 plasma concentration in patients with NTG, whereas a slightly higher ET level was observed in the patients with HTG with the GT genotype in comparison to those with the GG genotype (p = 0.001). The C1222T polymorphism significantly affected the plasma ET level in patients with NTG. The TT genotype carriers had the highest ET level, and the CC genotype carriers the lowest (p = 0.034). The AA variant genotype of the G231A polymorphism exhibited the highest ET level, while the GG variant genotype represented the lowest level (p = 0.033). No significant differences were observed regarding the endothelin levels and the frequency of notches, peripapillary atrophy, low blood pressure, cold extremities, or migraine in the two groups studied. Slightly lower endothelin plasma levels were observed in patients with optic disc hemorrhages in the NTG group (p = 0.05).

conclusionsPolymorphic variants of

Indexed as

Polymorphism, Single NucleotideAgedEndothelin-1Enzyme-Linked Immunosorbent AssayFemaleGenotyping TechniquesHumansIntraocular PressureLow Tension GlaucomaMaleReal-Time Polymerase Chain ReactionReceptor, Endothelin ARisk FactorsVisual AcuityEndothelin-1Receptor, Endothelin A

Identifiers

PMID27777505
PMCPMC5072545
OpenAlexW2539461747

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.