ArticleRadiologia brasileira
Changes seen on computed tomography of the chest in mildly symptomatic adult patients with sickle cell disease.
Article in Radiologia brasileira. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Quantification of chronic vascular remodeling in sickle cell disease.European radiology · 2026Article
- Relationship between ventilation heterogeneity and exercise intolerance in adults with sickle cell anemia.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Radiologist agreement on the quantification of bronchiectasis by high-resolution computed tomography.Radiologia brasileiraArticle
- Article
- Idiopathic interstitial pneumonias: review of the latest American Thoracic Society/European Respiratory Society classification.Radiologia brasileiraArticle
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6 authors.
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Abstract
objectiveTo describe and quantify the main changes seen on computed tomography of the chest in mildly symptomatic adult patients with sickle cell disease, as well as to evaluate the radiologist accuracy in determining the type of hemoglobinopathy. MATERIALS AND
methodsA prospective study involving 44 adult patients with sickle cell disease who underwent inspiration and expiration computed tomography of the chest. The frequency of tomography findings and the extent of involvement are reported. We also calculated radiologist accuracy in determining the type of hemoglobinopathy by analyzing the pulmonary alterations and morphology of the spleen.
resultsThe changes found on computed tomography scans, in descending order of frequency, were as follows: fibrotic opacities (81.8%); mosaic attenuation (56.8%); architectural distortion (31.8%); cardiomegaly (25.0%); lobar volume reduction (18.2%); and increased caliber of peripheral pulmonary arteries (9.1%). For most of the findings, the involvement was considered mild, five or fewer lung segments being affected. The accuracy in determining the type of hemoglobinopathy (HbSS group versus not HbSS group) was 72.7%.
conclusionIn adult patients with sickle cell disease, the main tomography findings reflect fibrotic changes. In addition, computed tomography can be helpful in differentiating among hemoglobinopathies.
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