ArticleMolecular psychiatry2017
Brain structure in pediatric Tourette syndrome.
Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Structural and functional alterations in the brain gray matter among Tourette syndrome patients: a multimodal meta-analysis of fMRI and VBM studies.Journal of neurology · 2025Pooled it
- Gray matter abnormalities in Tourette Syndrome: a meta-analysis of voxel-based morphometry studies.Translational psychiatry · 2021Pooled it
- Grey matter abnormalities in Tourette syndrome: an activation likelihood estimation meta-analysis.BMC psychiatry · 2021Pooled it
- Tourette syndrome research highlights from 2017.F1000Research · 2018Pooled it
- Function-Specific Localization in the Supplementary Motor Area: A Potential Effective Target for Tourette Syndrome.CNS neuroscience & therapeutics · 2025Trial
- Cortical Thickness and White Matter Surface Morphology in Tourette Syndrome: A Cohort Study.Annals of neurology · 2026Article
- Altered neurodevelopmental trajectories of brain structure in Tourette syndrome and Chronic Tic Disorders.medRxiv : the preprint server for health sciences · 2026Article
- Multimodal brain imaging neurotransmitter marker study of TD: a review of TCM effect mechanisms and precise diagnosis and treatment combining traditional Chinese and western medicine.American journal of translational research · 2026Review
- A Celsr3 Mutation Linked to Tourette Disorder Disrupts Cortical Dendritic Patterning and Striatal Cholinergic Interneuron Excitability.International journal of molecular sciences · 2025Article
- Insights into structural deviations in attention deficit hyperactivity disorder (ADHD) and comorbidities using big data-derived brain charts: a cross-sectional study.Quantitative imaging in medicine and surgery · 2025Article
- Identifying texture features from structural magnetic resonance imaging scans associated with Tourette's syndrome using machine learning.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Motor network organization in healthy development and chronic tic disorders.Brain communications · 2025Article
- Correlating clinical course with baseline subcortical shape in provisional tic disorder.CNS spectrums · 2024Article
- Vitamin D3 improves iminodipropionitrile-induced tic-like behavior in rats through regulation of GDNF/c-Ret signaling activity.European child & adolescent psychiatry · 2024Article
- Circulating retinol and 25(OH)D contents and their association with symptoms in children with chronic tic disorders.European child & adolescent psychiatry · 2024Article
- The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients.Journal of neurodevelopmental disorders · 2023Article
- Thalamo-cortical and cerebello-cortical functional connectivity in development.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Sex and gender in neurodevelopmental conditions.Nature reviews. Neurology · 2023Review
- Tourette syndrome: clinical features, pathophysiology, and treatment.The Lancet. Neurology · 2023Review
- Mapping a network for tics in Tourette syndrome using causal lesions and structural alterations.Brain communications · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
Previous studies of brain structure in Tourette syndrome (TS) have produced mixed results, and most had modest sample sizes. In the present multicenter study, we used structural magnetic resonance imaging (MRI) to compare 103 children and adolescents with TS to a well-matched group of 103 children without tics. We applied voxel-based morphometry methods to test gray matter (GM) and white matter (WM) volume differences between diagnostic groups, accounting for MRI scanner and sequence, age, sex and total GM+WM volume. The TS group demonstrated lower WM volume bilaterally in orbital and medial prefrontal cortex, and greater GM volume in posterior thalamus, hypothalamus and midbrain. These results demonstrate evidence for abnormal brain structure in children and youth with TS, consistent with and extending previous findings, and they point to new target regions and avenues of study in TS. For example, as orbital cortex is reciprocally connected with hypothalamus, structural abnormalities in these regions may relate to abnormal decision making, reinforcement learning or somatic processing in TS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.