ArticleScientific reports2016
Zebrafish as a new model to study effects of periodontal pathogens on cardiovascular diseases.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gingipain inhibitors as an innovative therapy for periodontal and associated-systemic diseases: a systematic review.Clinical oral investigations · 2025Pooled it
- Zebrafish study provides evidence forFrontiers in cellular and infection microbiology · 2026Article
- Gingipains protect Porphyromonas gingivalis from macrophage-mediated phagocytic clearance.PLoS pathogens · 2025Article
- Zebrafish larvae as a model for studying the impact of oral bacterial vesicles on tumor cell growth and metastasis.Human cell · 2024Article
- Intraperitoneal Injection of theInternational journal of molecular sciences · 2024Article
- Effects and mechanisms of Porphyromonas gingivalis outer membrane vesicles induced cardiovascular injury.BMC oral health · 2024Article
- Establishing a Zebrafish Model for Borrelia burgdorferi Infection Using Immersion and Microinjection Methods.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Periodontal bacteria influence systemic diseases through the gut microbiota.Frontiers in cellular and infection microbiology · 2024Review
- Targeted proteomics in a population-based study identifies serum PECAM-1 and TRIM21 as inflammation markers for periodontitis.Clinical oral investigations · 2023Article
- Endotoxin ofToxicological research · 2023Article
- Fusobacterium nucleatum mediates endothelial damage and increased permeability following single species and polymicrobial infection.Journal of periodontology · 2022Article
- Risk factors for bleeding after dental extractions in patients receiving antithrombotic drugs - A case control study.Journal of dental sciences · 2022Article
- Zebrafish as model for studies in dentistry.Journal of orthodontic science · 2022Review
- Implications ofFrontiers in cellular and infection microbiology · 2022Review
- Oral bacteria and leaky endothelial junctions in remote extraoral sites.The FEBS journal · 2021Article
- Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis.The FEBS journal · 2021Article
- Article
- [Research progress of correlation between periodontal pathogens and systemic diseases].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Review
- Identification of Novel Bacteriophages with Therapeutic Potential That TargetInfection and immunity · 2019Article
- Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection.The Journal of infectious diseases · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Porphyromonas gingivalis (Pg) is a keystone pathogen in the aetiology of chronic periodontitis. However, recent evidence suggests that the bacterium is also able to enter the bloodstream, interact with host cells and tissues, and ultimately contribute to the pathogenesis of cardiovascular disease (CVD). Here we established a novel zebrafish larvae systemic infection model showing that Pg rapidly adheres to and penetrates the zebrafish vascular endothelium causing a dose- and time-dependent mortality with associated development of pericardial oedemas and cardiac damage. The in vivo model was then used to probe the role of Pg expressed gingipain proteases using systemically delivered gingipain-deficient Pg mutants, which displayed significantly reduced zebrafish morbidity and mortality compared to wild-type bacteria. In addition, we used the zebrafish model to show efficacy of a gingipain inhibitor (KYT) on Pg-mediated systemic disease, suggesting its potential use therapeutically. Our data reveal the first real-time in vivo evidence of intracellular Pg within the endothelium of an infection model and establishes that gingipains are crucially linked to systemic disease and potentially contribute to CVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.