ArticleCirculation research2017
AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis.
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Article in Circulation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 54 citations in OpenAlex.
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Authors and funding
13 authors at 1 institution in 1 country.
Randa Abdel MalikFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).
Nina ZippelFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).
Timo FrömelFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).
Juliana HeidlerFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).
Sven ZukunftFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).
Barbara WalzogFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).
Nariman AnsariFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).
Francesco PampaloniFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).
Susanne WingertFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).
Michael A RiegerFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).
Ilka WittigFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).
Beate FisslthalerFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).
Ingrid FlemingFrom the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.). fleming@em.uni-frankfurt.de.
German Centre for Cardiovascular Research · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe AMP-activated protein kinase (AMPK) is stimulated by hypoxia, and although the AMPKα1 catalytic subunit has been implicated in angiogenesis, little is known about the role played by the AMPKα2 subunit in vascular repair.
objectiveTo determine the role of the AMPKα2 subunit in vascular repair. METHODS AND
resultsRecovery of blood flow after femoral artery ligation was impaired (>80%) in AMPKα2
conclusionsAMPKα2 regulates α-ketoglutarate generation, hypoxia-inducible factor-1α stability, and neutrophil survival, which in turn determine further myeloid cell recruitment and repair potential. The activation of AMPKα2 in neutrophils is a decisive event in the initiation of vascular repair after ischemia.
Indexed as
AMP-Activated Protein KinasesAnimalsApoptosisBlood VesselsEndothelial CellsHindlimbHypoxia-Inducible Factor 1, alpha SubunitIschemiaMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutMice, TransgenicNeutrophilsAMP-Activated Protein KinasesHypoxia-Inducible Factor 1, alpha SubunitPrkaa2 protein, mousediabetes mellitusischemiametabolomicsproteomicsvascular remodeling
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