Evidence map›Paper›PMID 27777102›Full record

ArticleNeurotoxicology2017

Atypical microglial response to biodiesel exhaust in healthy and hypertensive rats.

Christen L Mumaw, Michael Surace, Shannon Levesque, Urmila P Kodavanti, Prasada Rao S Kodavanti, Joyce E Royland, Michelle L Block

Open access · greenAbstract read
In one paragraph

Article in Neurotoxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Christen L MumawDepartment of Anatomy and Cell Biology, The Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Michael SuraceDepartment of Biochemistry & Molecular Biology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298, USA.
Shannon LevesqueDepartment of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298, USA.
Urmila P KodavantiEnvironmental Public Health Division, National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, USA.
Prasada Rao S KodavantiToxicity Assessment Division, National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Joyce E RoylandIntegrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, USA.
Michelle L BlockDepartment of Anatomy and Cell Biology, The Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address: mlblock@iupui.edu.
Environmental Protection Agency · USIndiana University – Purdue University Indianapolis · USVirginia Commonwealth University Medical Center · USResearch Triangle Park Foundation · US

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

Accumulating evidence suggests a deleterious role for urban air pollution in central nervous system (CNS) diseases and neurodevelopmental disorders. Microglia, the resident innate immune cells and sentinels in the brain, are a common source of neuroinflammation and are implicated in air pollution-induced CNS effects. While renewable energy, such as soy-based biofuel, is of increasing public interest, there is little information on how soy biofuel may affect the brain, especially in people with preexisting disease conditions. To address this, male spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats were exposed to 100% Soy-based Biodiesel Exhaust (100SBDE; 0, 50, 150 and 500μg/m

Indexed as

Aconitate HydrataseAnimalsAntioxidantsBiofuelsCalcium-Binding ProteinsChemokine CX3CL1CytokinesDose-Response Relationship, DrugHypertensionMaleMicrofilament ProteinsMicrogliaOxidative StressRatsRats, Inbred SHRRats, Inbred WKY3-nitrotyrosineAconitate HydrataseAif1 protein, ratAntioxidantsBiofuelsCalcium-Binding ProteinsChemokine CX3CL1CytokinesMicrofilament ProteinsRNA, MessengerTyrosineTyrosine 3-MonooxygenaseVehicle EmissionsAir pollutionAtypical activationBiodieselBrainMicrogliaNeurotoxicity

Identifiers

PMID27777102
PMCPMC6757344
OpenAlexW2534289363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.