ArticleMayo Clinic proceedings2016
Association of Physical Activity and Inflammation With All-Cause, Cardiovascular-Related, and Cancer-Related Mortality.
Article in Mayo Clinic proceedings, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose-response meta-analysis of large prospective studies.British journal of sports medicine · 2023Pooled it
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Correspondence: Highlighting the importance of immune system changes induced by physical activity and green tea in cancer management.Cancer cell international · 2025Article
- Combined influence of physical activity and C-reactive protein to albumin ratio on mortality among older cancer survivors in the United States: a prospective cohort study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024Article
- Association between the systemic inflammatory response index and mortality in patients with sarcopenia.PloS one · 2024Article
- Impact of pre- and post-diagnosis physical activity on the mortality of patients with cancer: Results from the Health Examinees-G study in Korea.Cancer medicine · 2023Article
- Association of Cardiovascular Mortality with Concurrent Coronary Artery Calcification and Physical Activity: A Cohort Study.Medicina (Kaunas, Lithuania) · 2023Article
- Occupational physical activity: the good, the bad, and the proinflammatory.Frontiers in medicine · 2023Review
- Walking Engagement in Mexican Americans Who Participated in a Community-Wide Step Challenge in El Paso, TX.International journal of environmental research and public health · 2021Article
- Smartphone-recorded physical activity for estimating cardiorespiratory fitness.Scientific reports · 2021Article
- Physical activity attenuates the associations of systemic immune-inflammation index with total and cause-specific mortality among middle-aged and older populations.Scientific reports · 2021Article
- Changes in Lifestyle and Dietary Habits during COVID-19 Lockdown in Italy: Results of an Online Survey.Nutrients · 2021Article
- Prediction of incident hypertension with the coronary artery calcium score based on the 2017 ACC/AHA high blood pressure guidelines.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- The Impact of a Structured, Supervised Exercise Program on Daily Step Count in Sedentary Older Adults With and Without HIV.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Physical Activity and Mortality in Cancer Survivors: A Systematic Review and Meta-Analysis.JNCI cancer spectrum · 2020Article
- Trajectories of physical activity from midlife to old age and associations with subsequent cardiovascular disease and all-cause mortality.Journal of epidemiology and community health · 2020Article
- Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy.Journal of clinical medicine · 2019Article
- Habitual recreational physical activity is associated with significantly improved survival in cancer patients: evidence from the Roswell Park Data Bank and BioRepository.Cancer causes & control : CCC · 2019Article
- Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients.Toxins · 2018Observational
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between physical activity (PA) and risk of mortality in a large middle-aged cohort stratified by inflammatory status. PATIENTS AND
methodsA total of 336,560 individuals (mean age, 39.7 years; 58% male) who underwent comprehensive health screenings were enrolled in this prospective cohort study. They were grouped according to self-reported PA level using a questionnaire: no regular PA with a sedentary lifestyle, regular but insufficient PA (below the guidelines), sufficient PA (concordant with the guidelines), and health-enhancing PA. Inflammation was assessed via high-sensitivity C-reactive protein (hsCRP) level. Study end points were all-cause, cardiovascular-related, and cancer-related mortality.
resultsDuring the 1,976,882 person-years of follow-up (median follow-up duration, 6.17 years), 2062 deaths occurred. Compared with a sedentary lifestyle, the hazard ratios (95% CIs) on the multivariable Cox proportional hazards regression analyses for all-cause mortality by PA level were 0.95 (0.84-1.07), 0.85 (0.72-0.99), and 0.75 (0.60-0.93) (P for trend=.003), and those for cardiovascular- and cancer-related mortality were 0.95, 0.80, and 0.55 (P for trend=.05) and 0.82, 0.83, and 0.78 (P for trend=.01), respectively. Compared with participants with low hsCRP levels and any regular PA, those with high hsCRP levels and no regular PA had a significantly higher risk of mortality (1.59 [1.38-1.84]).
conclusionHigher PA levels were associated with a dose-dependent reduced risk of cardiovascular-related, cancer-related, and all-cause mortality. Individuals with high hsCRP levels and no regular PA had the highest risk of mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.