ReviewSeminars in oncology nursing2016
Biological Basis for the Clustering of Symptoms.
Review in Seminars in oncology nursing, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Associations between inflammatory biomarkers, symptoms, treatment toxicities and quality of life in people with advanced cancer receiving systemic anti-cancer treatments: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Common patient-reported sources of cancer-related distress in adults with cancer: A systematic review.Cancer medicine · 2024Pooled it
- Chronic Obstructive Pulmonary Disease Symptom Cluster Composition, Associated Factors, and Methodologies: A Systematic Review.Western journal of nursing research · 2022Pooled it
- Symptom clusters in patients receiving chemotherapy: A systematic review.BMJ supportive & palliative care · 2022Pooled it
- Symptom Clusters in Head and Neck Cancer: A Systematic Review and Conceptual Model.Seminars in oncology nursing · 2021Pooled it
- Symptom clusters experienced by breast cancer patients at various treatment stages: A systematic review.Cancer medicine · 2021Pooled it
- The Role of Inflammation in the Pain, Fatigue, and Sleep Disturbance Symptom Cluster in Advanced Cancer.Journal of pain and symptom management · 2018Trial
- "Walk for Life": A Feasibility Randomised Controlled Trial of Guolin Qigong for Fatigue, Sleep Disturbance and Depression Symptom Cluster in Cancer Survivors.Integrative cancer therapiesTrial
- Towards an understanding of disturbed sleep phenotypes after traumatic spinal cord injury.Journal of rehabilitation medicine · 2026Observational
- Transcutaneous vagus nerve stimulation in breast cancer: a neuroimmune model to improve quality of life.Frontiers in oncology · 2026Article
- Economic Insecurities and Patient-Reported Outcomes Among Cancer Survivors after Receiving External Beam Radiotherapy for Prostate Cancer: A Cross-sectional Study.Urologic nursing · 2026Article
- Biobehavioral correlates of multidimensional fatigue in men with prostate cancer: A secondary data analysis.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2025Observational
- Profiling of psychoneurological symptoms in newly diagnosed head and neck cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Article
- Symptom clusters and sentinel symptoms in breast cancer survivors based on self-reported outcomes:A cross-sectional survey.Journal of clinical nursing · 2025Article
- Symptoms, Symptom Profiles, and Healthcare Utilization in Patients with Hematologic Malignancies: A Retrospective Observational Cohort Study and Latent Class Analysis.Current oncology (Toronto, Ont.) · 2025Observational
- Qigong in the care of breast cancer survivors with diabetes.Asia-Pacific journal of oncology nursing · 2024Article
- A longitudinal study of symptom cluster latent profiles in ovarian cancer patients undergoing chemotherapy.Cancer medicine · 2024Article
- Effects of nonpharmacological interventions on symptom clusters in breast cancer survivors: A systematic review of randomized controlled trials.Asia-Pacific journal of oncology nursing · 2024Review
- Chemotherapy-related symptom networks in distinct subgroups of Chinese patients with gastric cancer.Asia-Pacific journal of oncology nursing · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 1 country.
Funding
Abstract
objectivesIdentification of biologic pathways of symptom clusters is necessary to develop precision therapies for distressing symptoms. This review examined extant literature evaluating relationships between biomarkers and symptom clusters in cancer survivors. DATA SOURCES: PubMed, CINAHL, Web of Science and Cochrane Library were searched using terms "biological markers" or "biomarkers" and "symptom cluster" or "symptom complex" or "multiple symptoms."
conclusionBiomarkers related to inflammation (eg, cytokines) were the most studied and showed the most significant relationships with clusters of symptoms. This review suggests that clustering of symptoms related to cancer or cancer therapy is linked to immune/inflammatory pathways. IMPLICATIONS FOR NURSING PRACTICE: Understanding the etiology of symptom clusters may guide future nursing interventions for symptom management.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.