Evidence map›Paper›PMID 27776761›Full record

Trial reportJournal of acupuncture and meridian studies2016

Intraoperative Low-frequency Electroacupuncture under General Anesthesia Improves Postoperative Recovery in a Randomized Trial.

Dennis Grech, Zhifeng Li, Patrick Morcillo, Evelyne Kalyoussef, David D Kim, Alex Bekker, Luis Ulloa

Registry-linked trialOpen access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of acupuncture and meridian studies, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01937520 (Acupuncture for Reduction of Inflammation in Thyroid and Parathyroid Surgery), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
10.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01937520 nacompletednot on this map

Acupuncture for Reduction of Inflammation in Thyroid and Parathyroid Surgery: Randomized, Prospective Double Blind Pilot Clinical Trial

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2013 to 2015Enrolled20ConditionsThyroid or Parathyroid SurgeryArmsacupuncture, no acupuncture
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Effect of Acupoint Therapies on Postoperative Sleep Quality: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dennis GrechDepartment of Anesthesiology, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Zhifeng LiLaboratory of Surgical Immunology, Department of Surgery, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Patrick MorcilloLaboratory of Surgical Immunology, Department of Surgery, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Evelyne KalyoussefDepartment of Otolaryngology, Head and Neck Surgery, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
David D KimDepartment of Anesthesiology, New Jersey Medical School, Rutgers University, Newark, NJ, USA; Departments of Pharmacology and Physiology, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Alex BekkerDepartment of Anesthesiology, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Luis UlloaLaboratory of Surgical Immunology, Department of Surgery, New Jersey Medical School, Rutgers University, Newark, NJ, USA. Electronic address: Luis.Ulloa@Rutgers.edu.
Rutgers, The State University of New Jersey · US

Funding

Dopaminergic regulation of the immune systemR01GM114180 · NIGMS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ULLOA, LUIS · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM114180
6 · The paper itself

Abstract

Neuronal stimulation improves physiological responses to infection and trauma, but the clinical potential of this strategy is unknown. We hypothesized that transdermal neural stimulation through low-frequency electroacupuncture might control the immune responses to surgical trauma and expedite the postoperative recovery. However, the efficiency of electroacupuncture is questioned due to the placebo effect. Here, electroacupuncture was performed on anesthetized patients to avoid any placebo. This is a prospective double-blinded pilot trial to determine whether intraoperative electroacupuncture on anesthetized patients improves postoperative recovery. Patients with electroacupuncture required 60% less postoperative analgesic, even they had pain scores similar to those in the control patients. Electroacupuncture prevented postoperative hyperglycemia and attenuated serum adrenocorticotropic hormone in the older and heavier group of patients. From an immunological perspective, electroacupuncture did not affect the protective immune responses to surgical trauma, including the induction of interleukin-6 and interleukin-10. The most significant immunological effect of electroacupuncture was enhancing transforming growth factor-β1 production during surgery in the older and lighter group of patients. These results suggest that intraoperative electroacupuncture on anesthetized patients can reduce postoperative use of analgesics and improve immune and stress responses to surgery.

Indexed as

ElectroacupunctureAdultAgedAnesthesia, GeneralFemaleHumansInterleukin-10Interleukin-6MaleMiddle AgedPain MeasurementPostoperative PainProspective StudiesIL10 protein, humanIL6 protein, humanInterleukin-10Interleukin-6cytokineselectroacupunctureinflammationpainphysiological stresssurgery

Identifiers

PMID27776761
PMCPMC6289585
OpenAlexW2333541302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.