Evidence map›Paper›PMID 27776757›Full record

ArticleAmerican journal of surgery2016

Utilization of iron (III)-doped nanoshells for in vivo marking of nonpalpable tumors using a VX2 rabbit model.

Erin P Ward, James Wang, Natalie Mendez, Jian Yang, Chris Barback, Jessica Wang-Rodriguez, William Trogler, Andrew C Kummel, Sarah Blair

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Erin P WardMoores Cancer Center, University of California, 3855 Heath Science Dr MC 0987, San Diego, CA 92093, USA.
James WangDepartment of Nanoengineering, University of California, San Diego, CA, USA.
Natalie MendezDepartment of Chemistry and Biochemistry, University of California, San Diego, CA, USA.
Jian YangDepartment of Chemistry and Biochemistry, University of California, San Diego, CA, USA.
Chris BarbackMoores Cancer Center, University of California, 3855 Heath Science Dr MC 0987, San Diego, CA 92093, USA.
Jessica Wang-RodriguezDepartment of Pathology, University of California, San Diego, CA, USA.
William TroglerDepartment of Chemistry and Biochemistry, University of California, San Diego, CA, USA.
Andrew C KummelDepartment of Chemistry and Biochemistry, University of California, San Diego, CA, USA.
Sarah BlairMoores Cancer Center, University of California, 3855 Heath Science Dr MC 0987, San Diego, CA 92093, USA. Electronic address: slblair@ucsd.edu.

Funding

Non-Circulating Microparticles for Improved Localization and Resection CancerR33CA177449 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BLAIR, SARAH L · 2014 to 2016
$1.1M
Non-circulating microparticles for improved localization and resection cancerR21CA151140 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BLAIR, SARAH L · 2011 to 2012
$274k
In Vivo Analysis of Stationary Gas Filled Hollow Iron Doped Silica NanoshellsF31CA174276 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIBERMAN, ALEXANDER · 2013 to 2014
$73k
NCI NIH HHS F31 CA174276NCI NIH HHS R21 CA151140NCI NIH HHS R33 CA177449
6 · The paper itself

Abstract

backgroundWe aimed to evaluate the potential for ultrasound (US) visible biodegradable nanoshells (NS) as an alternative to wire-guided localization for nonpalpable tumors in vivo.

methodsVX2 tumor was injected in bilateral thighs of 22 New Zealand rabbits and after 5 to 10 days, 1 tumor was marked with a wire as a control and the contralateral tumor was injected with 1 mL of 500 nm gas-filled silica NS under Doppler US. Tumors were excised after 24 hours. Chi-square was used for significance, P = .05.

resultsOne rabbit was excluded on postoperative day 1 due to equipment failure, no ill effects were observed from the NS. The NS were used to localize and resect 100% of marked tissue, 4/21 wires were displaced (P < .05).

conclusionsWe have shown that preoperatively injected US visible silica NS can be successfully used to mark nonpalpable tumors in vivo more consistently than WL.

Indexed as

Ferric CompoundsNanoshellsSurgery, Computer-AssistedUltrasonography, InterventionalAnimalsBreast NeoplasmsDisease Models, AnimalFemaleRabbitsFerric CompoundsBreast cancerNanoshellsNonpalpableSilica nanoparticlesTumor localization

Identifiers

PMID27776757
PMCPMC5138116

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.