Trial reportThe Journal of pediatrics2017
Acute Perinatal Sentinel Events, Neonatal Brain Injury Pattern, and Outcome of Infants Undergoing a Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy.
Trial report in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005772 (Randomized Controlled Trial of Hypothermia for Hypoxic-Ischemic Encephalopathy in Term Infants), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial of Hypothermia for Hypoxic-Ischemic Encephalopathy in Term Infants
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Neonatal encephalopathy: a systematic review of reported treatment outcomes.BMJ paediatrics open · 2024Pooled it
- Therapeutic hypothermia in neonatal hypoxic encephalopathy: A systematic review and meta-analysis.Journal of global health · 2022Pooled it
- Time to Reaching Target Cooling Temperature and 2-year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy.The Journal of pediatrics · 2024Trial
- Limitations of Conventional Magnetic Resonance Imaging as a Predictor of Death or Disability Following Neonatal Hypoxic-Ischemic Encephalopathy in the Late Hypothermia Trial.The Journal of pediatrics · 2021Trial
- Differences in Management of Neonates with Hypoxic-Ischemic Encephalopathy (HIE) by Level of Neonatal Care Provided at Birth: Insights from a Referral-Based Cohort in the Canton of Zurich, Switzerland.Children (Basel, Switzerland) · 2026Article
- Brain MRI findings in near-term and term infants admitted to a neonatal ward.Frontiers in neurology · 2026Article
- Emerging modalities for neuroprognostication in neonatal encephalopathy: harnessing the potential of artificial intelligence.Pediatric research · 2025Review
- Shifting outlooks after neonatal encephalopathy in the era of therapeutic hypothermia.Pediatric research · 2025Review
- Translational Potential of Stem Cell-based Therapies in the Treatment of Neonatal Hypoxic-ischemic Brain Injury.Stem cell reviews and reports · 2025Review
- Antioxidant Therapy in Neonatal Hypoxic Ischemic Encephalopathy: Adjuvant or Future Alternative to Therapeutic Hypothermia?Metabolites · 2024Review
- Hypothermia for Hypoxic-ischemic Encephalopathy: Second-generation Trials to Address Gaps in Knowledge.Clinics in perinatology · 2024Review
- Brain MRI Injury Patterns across Gestational Age among Preterm Infants with Perinatal Asphyxia.Neonatology · 2024Article
- The influence of late prematurity on the encephalopathy exam of infants with neonatal encephalopathy.Journal of neonatal-perinatal medicine · 2023Article
- Neuroprotection for hypoxic-ischemic encephalopathy: Contributions from the neonatal research network.Seminars in perinatology · 2022Review
- Association of perinatal sentinel events, placental pathology and cerebral MRI in neonates with hypoxic-ischemic encephalopathy receiving therapeutic hypothermia.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Neuroimaging in the term newborn with neonatal encephalopathy.Seminars in fetal & neonatal medicine · 2021Review
- Prognostic value of neonatal EEG following therapeutic hypothermia in survivors of hypoxic-ischemic encephalopathy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Article
- Velamentous cord insertion, ischemic-hypoxic encephalopathy, and neurological rehabilitation: A case reportBiomedica : revista del Instituto Nacional de Salud · 2021Article
- Therapeutic hypothermia for hypoxic-ischemic encephalopathy after perinatal sentinel events: less brain injury on MRI and improved neurodevelopmental outcome at 18-36 months.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Infants with perinatal sentinel events in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Hypothermia for Encephalopathy Trial had more basal ganglia and thalamus lesions on brain magnetic resonance imaging but similar neurodevelopmental outcomes at 18 months of age than infants without perinatal sentinel events. Outcomes correlated with the neonatal magnetic resonance imaging findings.
trial registrationClinicalTrials.gov: NCT00005772.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.