ArticleBiological psychiatry2017
Preadolescent Adversity Programs a Disrupted Maternal Stress Reactivity in Humans and Mice.
Article in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01700374 (Prepubertal Adversity Effect on Maternal Arousal, Preterm Birth and Infant Stress Response), which is not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prepubertal Adversity Effect on Maternal Arousal, Preterm Birth and Infant Stress Response
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Adverse childhood experiences and maternal anxiety and depression: a meta-analysis.BMC psychiatry · 2021Pooled it
- Intergenerational continuity of parent-child separation: implications for child allergies and total IgE in China.Pediatric research · 2026Article
- Family dominant hypothesis for the effect of family of origin on the mental health of offspring: evidence, mechanism, and implications.Frontiers in psychiatry · 2026Article
- Peripheral Blood Transcriptomic Features Distinguishing Postpartum Depression from Major Depressive Disorder and Healthy Postpartum Controls.International journal of women's health · 2026Article
- Appetitive maternal behavior in mice is resistant to perinatal chronic variable stress and perinatal chronic corticosterone treatment.Hormones and behavior · 2026Article
- Patterns of Adverse Childhood Experiences and Postpartum Depressive Symptoms.Journal of child & adolescent trauma · 2025Article
- Stress during puberty and adulthood pregnancy impact histone acetylation regulators in the hypothalamus.Neuroscience · 2025Article
- Can social adversity alter the epigenome, trigger oral disease, and affect future generations?Irish journal of medical science · 2024Review
- The impact of pubertal stress and adult hormone exposure on the transcriptome of the developing hypothalamus.bioRxiv : the preprint server for biology · 2024Article
- Allopregnanolone and mood in the peripartum: a longitudinal assessment in healthy women.Frontiers in behavioral neuroscience · 2024Article
- Chemogenetic activation of CRF neurons as a model of chronic stress produces sex-specific physiological and behavioral effects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The link between childhood traumatic events and the continuum of premenstrual disorders.Frontiers in psychiatry · 2024Article
- The impact of pubertal stress and adult hormone exposure on the transcriptome of the developing hypothalamus.Stress (Amsterdam, Netherlands) · 2024Article
- Recalibration of the stress response system over adult development: Is there a perinatal recalibration period?Development and psychopathology · 2023Review
- Is There an Inflammatory Profile of Perinatal Depression?Current psychiatry reports · 2023Review
- Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner.Biology of sex differences · 2023Article
- Enduring impact of childhood adversity: Affective modulation of acoustic startle response during pregnancy and postpartum.Physiology & behavior · 2023Article
- Genome-wide Signatures of Early-Life Stress: Influence of Sex.Biological psychiatry · 2022Review
- In search of sex-related mediators of affective illness.Biology of sex differences · 2021Review
- Prenatal stress-induced disruptions in microbial and host tryptophan metabolism and transport.Behavioural brain research · 2021Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAdverse childhood experiences (ACEs) are one of the greatest predictors of affective disorders for women. Periods of dynamic hormonal flux, including pregnancy, exacerbate the risk for affective disturbance and promote hypothalamic-pituitary-adrenal (HPA) axis dysregulation, a key feature of affective disorders. Little is understood as to how stress experienced in late childhood, defined as preadolescence, alters the programming unique to this period of brain maturation and its interaction with the hormonal changes of pregnancy and postpartum.
methodsPreadolescent female mice were exposed to chronic stress and examined for changes in their HPA axis during pregnancy and postpartum, including assessment of maternal-specific stress responsiveness and transcriptomics of the paraventricular nucleus of the hypothalamus. Translationally, pregnant women with low or high ACEs were examined for their maternal stress responsiveness.
resultsAs predicted, preadolescent stress in mice resulted in a significant blunting of the corticosterone response during pregnancy. Transcriptomic analysis of the paraventricular nucleus revealed widespread changes in expression of immediate early genes and their targets, supporting the likely involvement of an upstream epigenetic mechanism. Critically, in our human studies, the high ACE women showed a significant blunting of the HPA response.
conclusionsThis unique mouse model recapitulates a clinical outcome of a hyporesponsive HPA stress axis, an important feature of affective disorders, during a dynamic hormonal period, and suggests involvement of transcriptional regulation in the hypothalamus. These studies identify a novel mouse model of female ACEs that can be used to examine how additional life adversity may provoke disease risk or resilience.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.