Evidence map›Paper›PMID 27776678›Full record

Trial reportJournal of substance abuse treatment2016

Cognitive Behavioral Therapy Improves Treatment Outcomes for Prescription Opioid Users in Primary Care Buprenorphine Treatment.

Brent A Moore, David A Fiellin, Christopher J Cutter, Frank D Buono, Declan T Barry, Lynn E Fiellin, Patrick G O'Connor, Richard S Schottenfeld

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of substance abuse treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04257214 (Identifying Optimal Psychosocial Interventions for Patients Receiving Office-Based Buprenorphine), which is not on this map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04257214 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation

Identifying Optimal Psychosocial Interventions for Patients Receiving Office-Based Buprenorphine

TypeinterventionalSponsorPhiladelphia College of Osteopathic MedicineRan2020 to 2026Enrolled340ConditionsOpioid Use DisorderArmsPsychosocial treatment
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Brent A MooreDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. Electronic address: brent.moore@yale.edu.
David A FiellinDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Christopher J CutterDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Frank D BuonoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Declan T BarryDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Lynn E FiellinDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Patrick G O'ConnorDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Richard S SchottenfeldDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Counseling for Primary Care Office-Based BuprenorphineR01DA019511 · NIDA · YALE UNIVERSITY · PI FIELLIN, DAVID · 2005 to 2009
$2.8M
Automated Recovery Line for Medication Assisted TreatmentR01DA034678 · NIDA · YALE UNIVERSITY · PI MOORE, BRENT A. · 2013 to 2015
$1.2M
NCATS NIH HHS UL1 TR001863NIDA NIH HHS R01 DA019511NIDA NIH HHS R01 DA034678
6 · The paper itself

Abstract

To determine whether treatment outcomes differed for prescription opioid and heroin use disorder patients, we conducted a secondary analysis of a 24-week (N=140) randomized trial of physician management (PM) or PM plus cognitive behavioral therapy (CBT) in primary care buprenorphine/naloxone treatment. Self-reported opioid use and urine toxicology analyses were obtained weekly. We examined baseline demographic differences between primary prescription opioid use patients (n=49) and primary heroin use patients (n=91) and evaluated whether treatment response differed by assigned condition. Compared to primary heroin use patients, primary prescription opioid use patients had marginally fewer years of opioid use, were less likely to have had a previous drug treatment or detoxification, and were less likely to report injection drug use. Although opioid abstinence only, and treatment retention did not differ by opioid use group, opioid category moderated the effect of CBT on urine samples negative for all drugs. Primary prescription opioid use patients assigned to PM-CBT had more than twice the mean number of weeks of abstinence for all drugs (7.6) than those assigned to PM only (3.6; p=.02), while primary heroin use patients did not differ by treatment. Findings suggest that examination of other factors that may predict response to behavioral interventions is warranted.

Indexed as

Outcome Assessment, Health CareAdultAnalgesics, OpioidBuprenorphineCognitive Behavioral TherapyCombined Modality TherapyFemaleHumansMaleOpiate Substitution TreatmentOpioid-Related DisordersSubstance-Related DisordersYoung AdultAnalgesics, OpioidBuprenorphineBuprenorphineCognitive behavioral therapyOpioid-related disordersTreatment outcome

Identifiers

PMID27776678
PMCPMC5119533
OpenAlexW2514706761

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.