ArticleWorld journal of surgical oncology2016
Clinical characteristics of synchronous colorectal cancers in Japan.
Article in World journal of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Clinicopathological and molecular profiling of sporadic synchronous multiple primary colorectal cancers: focus on microsatellite instability status.Journal of gastrointestinal oncology · 2026Article
- Laparoscopic surgery for synchronous double colorectal cancer with obstruction, plus small B cell lymphoma: a case report.Journal of surgical case reports · 2025Article
- Endoscopic Resection of Stage T1 Colorectal Adenocarcinoma Followed by Surgical Intervention: a Single-center Retrospective Study.Journal of gastrointestinal cancer · 2024Article
- Rare synchronous colorectal carcinoma with three pathological subtypes: A case report and review of the literature.World journal of clinical cases · 2023Article
- Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter study.BMC gastroenterology · 2023Article
- Molecular Typing and Clinical Characteristics of Synchronous Multiple Primary Colorectal Cancer.JAMA network open · 2022Article
- Three colonic cancers, two sites of complete occlusion, one patient: A case report.World journal of gastrointestinal surgery · 2021Article
- Synchronous Quadruple Colon Cancer With Two Lesions Previously Obscured by Ischemic Colitis, Plus Bladder Cancer and Thymoma: A Case Report.Annals of coloproctology · 2021Article
- Synchronous Colorectal Cancer: Improving Accuracy of Detection and Analyzing Molecular Heterogeneity-The Main Keys for Optimal Approach.Diagnostics (Basel, Switzerland) · 2021Article
- A Retrospective Study of Risk Factors for Symptomatic Anastomotic Leakage after Laparoscopic Anterior Resection of the Rectal Cancer without a Diverting Stoma.Gastroenterology research and practice · 2020Article
- Multiplicity of Advanced T Category-Tumors Is a Risk Factor for Survival in Patients with Colorectal Carcinoma.Journal of pathology and translational medicine · 2018Article
- The added clinical value of performing CT colonography in patients with obstructing colorectal carcinoma.Gastroenterology report · 2018Article
- The molecular landscape of synchronous colorectal cancer reveals genetic heterogeneity.Carcinogenesis · 2018Article
- The Complex Puzzle of Interactions Among Functional Food, Gut Microbiota, and Colorectal Cancer.Frontiers in oncology · 2018Review
- CT volumetric measurement of colorectal cancer helps predict tumor staging and prognosis.PloS one · 2017Article
- Article
- Synchronous Recto-Sigmoid Colorectal Carcinomas With Microsatellite Instability and an Activating PIK3CA Mutation.Journal of investigative medicine high impact case reportsArticle
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10 authors.
Funding
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Abstract
backgroundIncidence and clinical characteristics of synchronous colorectal cancer (sCRC) patients significantly vary among studies, likely due to differences in surveillance methodology. If remain undetected, sCRC can progress to more advanced stages seriously aggravating patient prognosis. We studied the incidence and clinicopathological characteristics of Japanese patients with sCRCs who underwent surgery for primary CRC and received exhaustive perioperative surveillance.
methodsWe recruited 1005 patients with surgically resected CRCs between January 2007 and December 2011. The associations of clinical and pathological factors with sCRC development were assessed by univariate and multivariate logistic regression.
resultsEighty-four patients (8.4 %) developed sCRCs, 16 of them (19.0 %) harboring three or more cancers. Companion sCRCs were smaller and earlier stage than the index lesion (P < 0.0001). In multivariate analysis, advanced age (odds ratio (OR) 1.03 per year; P = 0.009) and left colon tumor location (OR 1.78; P = 0.013) are associated with higher risk of sCRCs, particularly in females. Overall survival did not differ between solitary CRC and sCRC (P = 0.62).
conclusionsOur results highlight the importance of perioperative colonoscopy examination to ensure the absence of sCRCs that, being small and early staged, are more difficult to detect. The incidence of sCRC, and notably of triple or more sCRCs, was higher than previously recognized. Because they are also significantly higher than expected by merely stochastic accumulation of individual cancerous lesions, we suggest that the occurrence of many sCRC reflects a hitherto uncharacterized predisposition condition.
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