Evidence map›Paper›PMID 27776523›Full record

ArticleBMC complementary and alternative medicine2016

In vitro anti-HIV and antioxidant activity of Hoodia gordonii (Apocynaceae), a commercial plant product.

Petrina Kapewangolo, Michael Knott, Regina E K Shithigona, Sylvia L Uusiku, Martha Kandawa-Schulz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.International journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Petrina KapewangoloDepartment of Chemistry and Biochemistry, Faculty of Science, University of Namibia, P/Bag 13301, Windhoek, Namibia. pkapewangolo@unam.na.
Michael KnottSchool of Pharmacy, University of Namibia, P/Bag 13301, Windhoek, Namibia.
Regina E K ShithigonaDepartment of Chemistry and Biochemistry, Faculty of Science, University of Namibia, P/Bag 13301, Windhoek, Namibia.
Sylvia L UusikuDepartment of Chemistry and Biochemistry, Faculty of Science, University of Namibia, P/Bag 13301, Windhoek, Namibia.
Martha Kandawa-SchulzDepartment of Chemistry and Biochemistry, Faculty of Science, University of Namibia, P/Bag 13301, Windhoek, Namibia.
University of Namibia · NA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHoodia gordonii products are widely commercialized for anti-obesity purposes; however, minimal research is available on the other health properties demonstrated by this popular herbal plant.

methodsH. gordonii crude extracts (ethanol and ethyl acetate) were assayed for in vitro anti-HIV-1 protease (PR), reverse transcriptase (RT) and integrase activity. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) and reducing power assays were used for the antioxidant analysis. In addition, qualitative and quantitative phytochemical analyses of the extracts were determined using standard methods.

resultsH. gordonii extract demonstrated good inhibition against HIV RT with IC

conclusionThis data suggests that H. gordonii has good in vitro inhibition against selected HIV-1 enzymes as well as antioxidant properties, suggesting new potential uses for this commercial plant.

Indexed as

AntioxidantsBiphenyl CompoundsHIV ProteaseHIV Reverse TranscriptaseHoodiaPhenolsPicratesPlant ExtractsReverse Transcriptase InhibitorsTannins1,1-diphenyl-2-picrylhydrazylAntioxidantsBiphenyl CompoundsHIV ProteaseHIV Reverse TranscriptasePhenolsPicratesPlant ExtractsReverse Transcriptase InhibitorsTanninsAntioxidant activityHIV PR inhibitorHIV RT inhibitorHoodia gordoniiPhytochemicals

Identifiers

PMID27776523
PMCPMC5078957
OpenAlexW2538834283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.