Evidence map›Paper›PMID 27776477›Full record

ArticleBMC genomics2016

Short- and long-term effects of

Soren Impey, Timothy Jopson, Carl Pelz, Amanuel Tafessu, Fatema Fareh, Damian Zuloaga, Tessa Marzulla, Lara-Kirstie Riparip, Blair Stewart, Susanna Rosi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Long-Term Sex- and Genotype-Specific Effects ofInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Soren ImpeyOregon Stem Cell Center and Department of Pediatrics, Oregon Health and Science University, Portland, OR, 97239, USA. impeys@ohsu.edu.
Timothy JopsonBrain and Spinal Injury Center, University of California, San Francisco, San Francisco, CA, 94110, USA.
Carl PelzOregon Stem Cell Center and Department of Pediatrics, Oregon Health and Science University, Portland, OR, 97239, USA.
Amanuel TafessuOregon Stem Cell Center and Department of Pediatrics, Oregon Health and Science University, Portland, OR, 97239, USA.
Fatema FarehOregon Stem Cell Center and Department of Pediatrics, Oregon Health and Science University, Portland, OR, 97239, USA.
Damian ZuloagaDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, 97239, USA.
Tessa MarzullaDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, 97239, USA.
Lara-Kirstie RiparipBrain and Spinal Injury Center, University of California, San Francisco, San Francisco, CA, 94110, USA.
Blair StewartDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, 97239, USA.
Susanna RosiBrain and Spinal Injury Center, University of California, San Francisco, San Francisco, CA, 94110, USA.
Mitchell S TurkerOregon Institute of Occupational Health Sciences and Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, 97239, USA.
Jacob RaberDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, 97239, USA. raberj@ohsu.edu.ORCID 0000-0002-9861-9893

Funding

BIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4M
NIDA NIH HHS T32 DA007262
6 · The paper itself

Abstract

backgroundAstronauts are exposed to

resultsAt the two-week time point, object recognition and network stability were impaired following irradiation at the 0.1 and 0.4 Gy dose, but not following irradiation at the 0.2 Gy dose. No impairments in object recognition or network stability were seen at the 20-week time point at any irradiation dose used. Consistent with this pattern, the significance of pathways for gene categories for 5hmC was lower, though not eliminated, at the 20-week time point compared to the 2-week time point. Similarly, significant changes were observed for 5mC gene pathways at the 2-week time point, but no significant gene categories were observed at the 20-week time point. Only the 5hmC changes tracked with gene expression changes.

conclusionsDose- and time-dependent epigenomic remodeling in the hippocampus following

Indexed as

IronRadiation, IonizingAnimalsCA1 Region, HippocampalCluster AnalysisCognitionDNA MethylationEpigenesis, GeneticGene Expression ProfilingGene Expression RegulationGene OntologyHippocampusImmunohistochemistryMaleMaze LearningMiceIronCognitionDNA methylationGene expressionHippocampusNetwork stability

Identifiers

PMID27776477
PMCPMC5078898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.